1. Metabolic Enzyme/Protease
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Phospholipase
    TRP Channel
  3. N-(p-amylcinnamoyl) Anthranilic Acid

N-(p-amylcinnamoyl) Anthranilic Acid (Synonyms: ACA)

Cat. No.: HY-118628 Purity: 98.81%
Handling Instructions

N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia.

For research use only. We do not sell to patients.

N-(p-amylcinnamoyl) Anthranilic Acid Chemical Structure

N-(p-amylcinnamoyl) Anthranilic Acid Chemical Structure

CAS No. : 110683-10-8

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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50 mg USD 80 In-stock
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100 mg USD 130 In-stock
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Description

N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3].

IC50 & Target

PLA2[1][2].
TRP channel[1][2]. Calcium-activated chloride channels[3].

In Vitro

N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) completely blocks ADPR-induced whole-cell currents and H2O2-induced Ca2+ signals (IC50=1.7 μM) in HEK293cells transfected with human TRPM2[1].
N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) also blocks currents through human TRPM8 and TRPC6 expressed in HEK293 cells[1].
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent of PLA22 inhibition[1].

Molecular Weight

337.41

Formula

C₂₁H₂₃NO₃

CAS No.

110683-10-8

SMILES

CCCCCC1=CC=C(C=C1)/C=C/C(NC2=CC=CC=C2C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (370.47 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9638 mL 14.8188 mL 29.6375 mL
5 mM 0.5928 mL 2.9638 mL 5.9275 mL
10 mM 0.2964 mL 1.4819 mL 2.9638 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.16 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
N-(p-amylcinnamoyl) Anthranilic Acid
Cat. No.:
HY-118628
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