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Cat. No.: HY-P11848

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P3LC7LC-P

P3LC7LC-P is a blood-brain barrier-permeable BRAG2 ligand with a K_D of 6.14 μM. P3LC7LC-P binds to BRAG2, thereby disrupting its interaction with the GluA2 subunit of the AMPA receptor and inhibiting glutamate-induced GluA2 endocytosis. P3LC7LC-P exerts neuroprotective effects in oxygen-glucose deprivation-induced and glutamate-induced neurotoxicity models, reduces ROS accumulation and inhibits apoptosis, and reduces cerebral infarct size in a rat model of transient middle cerebral artery occlusion. P3LC7LC-P can be used for the research of ischemic stroke.

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화학식: C₆₀H₇₃N₁₁O₁₅S₂
분자량:1252.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

P3LC7LC-P Chemical Structure

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All iGluR Isoforms :

In Vitro

P3LC7LC-P (10-50 μM; 24 h) shows no cytotoxicity against HT22 cells, and the cell viability remains above 80% at all tested doses, even at concentrations up to 50 μM^[1].
P3LC7LC-P (0.1-10 μM; 26 h) dose-dependently protects HT22 cells against glutamate-induced excitotoxicity, and restores cell viability to 91.92% at the concentration of 10 μM^[1].
P3LC7LC-P (0.1-10 μM) protects primary cortical neurons from glutamate-induced excitotoxic injury, and restores cell viability to 71.11% at a concentration of 10 μM^[1].
P3LC7LC-P (0.1-10 μM) protects primary cortical neurons against OGD/R-induced injury in a dose-dependent manner, and restores cell viability to 90.63% at 10 μM^[1].
P3LC7LC-P (10 μM; 26 h) significantly reduces glutamate-induced ROS accumulation in HT22 cells^[1].
P3LC7LC-P (10 μM; 26 h) significantly reduces glutamate-induced apoptosis of HT22 cells, decreasing the total apoptosis rate to 9.4%^[1].
P3LC7LC-P (10 μM; 26 h) reduces the Bax/Bcl-2 ratio and the expression level of activated caspase-3^[1].
P3LC7LC-P (10 μM; 3 h) significantly inhibits glutamate-induced GluA2 endocytosis in primary cortical neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HT22 cells
Concentration:

0.1, 1 and 10 μM
Incubation Time:

2 h (preincubation); 24 h (glutamate exposure)
Result:

Restored cell viability in a dose-dependent manner: viability reached 71.92% at 0.1 μM, 81.92% at 1 μM, and 91.92% at 10 μM.
Exceeded the protective efficacy of the positive control Tat-GluA2-3Y (68.72% viability at 10 μM).

Others (Intracellular Reactive Oxygen Species Inhibition Assay)^[1]

Cell Line:

HT22 cells exposed to glutamate
Concentration:

10 μM
Incubation Time:

2 h (preincubation); 24 h (glutamate exposure)
Result:

Reduced ROS production by approximately 50% relative to the glutamate-only group.
Showed reduced DCFH-DA fluorescence intensity confirmed by flow cytometry quantification.

Apoptosis Analysis^[1]

Cell Line:

HT22 cells exposed to glutamate
Concentration:

10 μM
Incubation Time:

2 h (preincubation); 24 h (glutamate exposure)
Result:

Reduced total HT22 cell apoptosis from 12.3% (glutamate alone) to 9.4%.
Showed efficacy comparable to Tat-GluA2-3Y (8.7% total apoptosis).
Confirmed reduced apoptotic nuclear condensation via Hoechst staining.

Western Blot Analysis^[1]

Cell Line:

HT22 cells exposed to glutamate
Concentration:

10 μM
Incubation Time:

2 h (preincubation); 24 h (glutamate exposure)
Result:

Significantly decreased the Bax/Bcl-2 ratio increased by glutamate alone.
Reduced cleaved caspase-3 activation induced by glutamate.
Showed efficacy comparable to Tat-GluA2-3Y.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	AUC_0-∞	MRT_0-t	MRT_0-∞	Brain-to-Plasma Ratio
Rat^[1]	8 mg/kg	s.c.	0.452 h	1 h	6930 ng/mL	12100 ng·h/mL	12100 ng·h/mL	1.24 h	1.24 h	21.3 %
Rat^[1]	8 mg/kg	i.v.	0.589 h	0.0833 h	6290 ng/mL	3250 ng·h/mL	3250 ng·h/mL	0.683 h	0.691 h	/

In Vivo

P3LC7LC-P (8 mg/kg; i.p.; single administration) significantly reduces the cerebral infarction volume to 21.00% in a rat transient middle cerebral artery occlusion (tMCAO) model of ischemic stroke^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (SD) (male)^[1]
Dosage:

8 mg/kg
Administration:

i.p.; single dose
Result:

Reduced cerebral infarct volume to 21.00%, compared to 31.51% in the tMCAO model group.

Chemical Information

분자량 1252.42
화학식 C₆₀H₇₃N₁₁O₁₅S₂
Sequence

{Tyr(4-Pentynoic acid)}-Lys-Cys-Gly-Tyr-Asn-Cys-Tyr-Gly (Disulfide bridge: Cys3-Cys7)
Sequence Shortening

{Tyr(4-Pentynoic acid)}-KCGYNCYG (Disulfide bridge: Cys3-Cys7)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Qin Y, et al. Stapled Peptides with Therapeutic Potential for Ischemic Stroke by Blocking the Endocytosis of GluA2 AMPAR. Journal of medicinal chemistry. 2026 Feb 12;69(3):3233-3251. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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P3LC7LC-P

All iGluR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

P3LC7LC-P Related Classifications

HY-P11848 Related Classifications