San45 

San45 is a nonselective dual amylin and calcitonin receptor agonist (DACRA) with nonselective potency relative to calcitonin receptor (CTR) and amylin 1 receptor (AMY₁R), and acts as a stabilizer of receptor-ligand complex and prolonged activator of cAMP signaling. San45 carries a conjugated lipid modification that can be used for the research of obesity^[1].

San45 (serial dilutions; 30 min) is a potent, nonselective dual amylin and calcitonin receptor agonist (DACRA) with similar potency at AMY₃R (pEC₅₀ = 10.66) and CTR (pEC₅₀ = 10.45) in HEK293-Flp-In cells^[1].
San45 (serial dilutions; 30 min) maintains potent, nonselective DACRA activity across CTR, AMY₁R, and AMY₃R in COS-1 cells, with pEC₅₀ values of 9.19 (CTR), 8.83 (AMY₁R), and 9.34 (AMY₃R)^[1].
San45 (4 μM (AMY₃R complex); 2 μM (CTR complex)) binds to AMY₃R via a distorted bypass conformation and to CTR via an alternative CT-like conformation, stabilized by its lipid modification, supporting its nonselective DACRA activity^[1].
San45 (serial dilutions; measured over cycles) exhibits prolonged cAMP signaling duration in COS-7 cells expressing AMY₁R, likely due to its lipid modification^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4331.97

C₁₉₄H₃₀₉N₅₁O₅₇S₂

Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Lys(γGlu-C16 acid)-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr (Disulfide bridge:Cys2-Cys7)

KCNTATCATQRLANFLVHSS-Lys(γGlu-C16 acid)-NFGPILPPTNVGSNTY (Disulfide bridge:Cys2-Cys7)

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• [1]. Cao J, et al. Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat Chem Biol. 2024;20(2):162-169.  [Content Brief]