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Cat. No.: HY-P11586

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San45

San45 is a nonselective dual amylin and calcitonin receptor agonist (DACRA) with nonselective potency relative to calcitonin receptor (CTR) and amylin 1 receptor (AMY₁R), and acts as a stabilizer of receptor-ligand complex and prolonged activator of cAMP signaling. San45 carries a conjugated lipid modification that can be used for the research of obesity.

For research use only. We do not sell to patients.

Formula: C₁₉₄H₃₀₉N₅₁O₅₇S₂
Molecular Weight:4331.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

San45 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

San45 (serial dilutions; 30 min) is a potent, nonselective dual amylin and calcitonin receptor agonist (DACRA) with similar potency at AMY₃R (pEC₅₀ = 10.66) and CTR (pEC₅₀ = 10.45) in HEK293-Flp-In cells^[1].
San45 (serial dilutions; 30 min) maintains potent, nonselective DACRA activity across CTR, AMY₁R, and AMY₃R in COS-1 cells, with pEC₅₀ values of 9.19 (CTR), 8.83 (AMY₁R), and 9.34 (AMY₃R)^[1].
San45 (4 μM (AMY₃R complex); 2 μM (CTR complex)) binds to AMY₃R via a distorted bypass conformation and to CTR via an alternative CT-like conformation, stabilized by its lipid modification, supporting its nonselective DACRA activity^[1].
San45 (serial dilutions; measured over cycles) exhibits prolonged cAMP signaling duration in COS-7 cells expressing AMY₁R, likely due to its lipid modification^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 4331.97
Formula C₁₉₄H₃₀₉N₅₁O₅₇S₂
Sequence

Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Lys(γGlu-C16 acid)-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr (Disulfide bridge:Cys2-Cys7)
Sequence Shortening

KCNTATCATQRLANFLVHSS-Lys(γGlu-C16 acid)-NFGPILPPTNVGSNTY (Disulfide bridge:Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cao J, et al. Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat Chem Biol. 2024;20(2):162-169. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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