Liraglutide acetate
Based on 40 publication(s) in Google Scholar
Liraglutide acetate is the acetate form of Liraglutide (HY-P0014), a glucagon-like peptide-1 (GLP-1) receptor agonist studied in type 2 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 1997361-86-0
- Formula: C172H265N43O51.xC2H4O2
- Molecular Weight:3751.20 (free base)
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Liraglutide acetate
More- Cell. 2025 Dec 24;188(26):7547-7570.e45 [Abstract]
- Nat Metab. 2024 May 20. [Abstract]
- Neuron. 2026 Mar 27:S0896-6273(26)00125-X. [Abstract]
- Acta Pharm Sin B. 2025 Dec;15(12):6382-6398. [Abstract]
- Sci Adv. 2022 Jul 22;8(29):eabn3773. [Abstract]
- Cardiovasc Diabetol. 2024 Jul 5;23(1):236. [Abstract]
- Brain Behav Immun. 2026 Jan 22:134:106295. [Abstract]
- Anal Chem. 2025 Jul 1;97(25):13465-13473. [Abstract]
- Life Sci. 2025 Aug 15:123912. [Abstract]
- J Nutr Biochem. 2025 Nov 26:110206. [Abstract]
- Int J Mol Sci. 2019 Apr 2;20(7). pii: E1629. [Abstract]
- Front Pharmacol. 2020 Feb 28;11:136. [Abstract]
- Int Immunopharmacol. 2025 Dec 11:169:116010. [Abstract]
- Int Immunopharmacol. 2024 Sep 27;142(Pt B):113258. [Abstract]
- Obesity. 2023 Nov;31(11):2676-2688. [Abstract]
- FASEB J. 2025 Nov 30;39(22):e71229. [Abstract]
- iScience. 2025 Apr 3;28(5):112344. [Abstract]
- iScience. 2023 Jan 7;26(2):105938. [Abstract]
- ACS Med Chem Lett. 2026 May 4;17(5):963-972. [Abstract]
- Sci Rep. 2025 Jan 12;15(1):1754. [Abstract]
- Sci Rep. 2024 Jun 14;14(1):13726. [Abstract]
- Biomedicines. 2023 Sep 27;11(10):2651. [Abstract]
- J Biol Chem. 2021 Jan-Jun:296:100807. [Abstract]
- Cardiovasc Toxicol. 2023 Apr;23(3-4):161-175. [Abstract]
- J Invest Surg. 2022 May;35(5):1012-1020. [Abstract]
- Microb Pathog. 2021 Jan;150:104645. [Abstract]
- Mol Med Rep. 2016 Oct;14(4):3662-8. [Abstract]
- Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F458-F468. [Abstract]
- J Biochem Mol Toxicol. 2026 Jun;40(6):e70913. [Abstract]
- Exp Biol Med. 2019 Oct;244(14):1193-1201. [Abstract]
- Clin Exp Pharmacol Physiol. 2024 Dec;51(12):e70003. [Abstract]
- Am J Physiol Regul Integr Comp Physiol. 2024 Oct 1;327(4):R410-R422. [Abstract]
- In Vitro Cell Dev Biol Anim. 2024 Oct;60(9):1046-1057. [Abstract]
- Cardiovasc Prev Pharmacother. 2025 Jul 24;7(3):61-72.
- bioRxiv. 2025 Jun 08.
- bioRxiv. 2025 Mar 4:2025.02.27.640645. [Abstract]
- ChemRxiv. 2025 Feb 25.
- Res Sq. 2024 Jun 13.
- SSRN. 2024 May 30.
- Research Square Preprint. 2021 Dec.
-
IF
-
Others
-
RT-PCR
-
WB
-
WB
Biological Activity
Chemical Information
-
CAS No. 1997361-86-0
-
Molecular Weight 3751.20 (free base)
-
Formula C172H265N43O51.xC2H4O2
-
Sequence
His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-{Lys(γGlu-C16 acid)}-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
-
Sequence Shortening
HAEGTFTSDVSSYLEGQAA-{Lys(γGlu-C16 acid)}-EFIAWLVRGRG
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (40)
-
Journal Impact Factor
-
Most Recent
-
Cell
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons. [Abstract]2025 Dec 24;188(26):7547-7570.e45 PMID: 41406962 -
Nat Metab
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice. [Abstract]2024 May 20. PMID: 38769396 -
Neuron
A septal inhibitory circuit constrains alcohol reward and mediates liraglutide's suppressive effects on alcohol intake in mice. [Abstract]2026 Mar 27:S0896-6273(26)00125-X. PMID: 41903537 -
Acta Pharm Sin B
2025 Dec;15(12):6382-6398. PMID: 41477334 -
Sci Adv
14-3-3-zeta mediates GLP-1 receptor agonist action to alter α cell proglucagon processing. [Abstract]2022 Jul 22;8(29):eabn3773. PMID: 35867787
Liraglutide acetate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2022 Jul 22;8(29):eabn3773. [Abstract]
Representative images of mouse islets immuno stained for insulin (red), 14-3-3-zeta (green), and DAPI (blue) in β cell GLP-1R WT and KO mice treated with saline (CTRL) or Liraglutide (LIRA) (100 nM).
Liraglutide acetate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2022 Jul 22;8(29):eabn3773. [Abstract]
Insulin secretion from islets isolated from β cell GLP-1R WT and KO mice in response to 11.1 mM Glucose with or without 100 nM Liraglutide.
Liraglutide acetate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2022 Jul 22;8(29):eabn3773. [Abstract]
α Cell Pcsk1 mRNA expression following treatment with conditioned media generated from islets of saline- and liraglutide-treated WT mice following 15 min and 2 hours of incubation with saline or Liraglutide (100 nM).
-
Cardiovasc Diabetol
Excessive accumulation of epicardial adipose tissue promotes microvascular obstruction formation after myocardial ischemia/reperfusion through modulating macrophages polarization. [Abstract]2024 Jul 5;23(1):236. PMID: 38970123 -
Brain Behav Immun
Activation of GLP-1R ameliorates microglial pyroptosis after spinal cord injury by restoring FANCC expression. [Abstract]2026 Jan 22:134:106295. PMID: 41580096 -
Anal Chem
Dissecting Hidden Liraglutide Oligomerization Pathways via Direct Mass Technology, Electron-Capture Dissociation, and Molecular Dynamics. [Abstract]2025 Jul 1;97(25):13465-13473. PMID: 40521838 -
Life Sci
Liraglutide attenuates doxorubicin-induced cardiomyocyte ferroptosis via DHHC7-mediated STAT3 palmitoylation. [Abstract]2025 Aug 15:123912. PMID: 40819789 -
J Nutr Biochem
Olive-derived elenolic acid surpasses metformin and rivals liraglutide in managing blood glucose and obesity in mouse models of type 2 diabetes. [Abstract]2025 Nov 26:110206. PMID: 41314560 -
Int J Mol Sci
2019 Apr 2;20(7). pii: E1629. PMID: 30986904 -
Front Pharmacol
The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome. [Abstract]2020 Feb 28;11:136. PMID: 32184723 -
Int Immunopharmacol
GLP-1 receptor agonist liraglutide facilitates rotator cuff healing by reducing tendon cell inflammation and endoplasmic reticulum stress through the GLP-1R-AMPK/SIRT1 pathway. [Abstract]2025 Dec 11:169:116010. PMID: 41386184 -
Int Immunopharmacol
Liraglutide alleviates ferroptosis in renal ischemia reperfusion injury via inhibiting macrophage extracellular trap formation. [Abstract]2024 Sep 27;142(Pt B):113258. PMID: 39340991 -
Obesity
Novel cannabinoid receptor 1 inverse agonist CRB-913 enhances efficacy of tirzepatide, semaglutide, and liraglutidein the diet-induced obesity mouse model. [Abstract]2023 Nov;31(11):2676-2688. PMID: 37840407 -
FASEB J
Liraglutide Mitigates Renal Injury in Diabetic Kidney Disease by Suppressing Podocyte Cholesterol Accumulation Through mTOR/VMP1-Regulated Autophagy. [Abstract]2025 Nov 30;39(22):e71229. PMID: 41246995 -
iScience
2025 Apr 3;28(5):112344. PMID: 40276762 -
iScience
2023 Jan 7;26(2):105938. PMID: 36718359 -
ACS Med Chem Lett
In Vitro Characterization of Agonist and Antagonist Peptide Binding Interaction Kinetics to GLP-1R in HEK293T Cells Using Surface Plasmon Resonance Microscopy. [Abstract]2026 May 4;17(5):963-972. PMID: 42157826 -
Sci Rep
Exploring Liraglutide's mechanism in reducing renal fibrosis: the Fsp1-CoQ10-NAD(P)H pathway. [Abstract]2025 Jan 12;15(1):1754. PMID: 39799153 -
Sci Rep
Liraglutide exhibits potential anti-tumor effects on the progression of intrahepatic cholangiocarcinoma, in vitro and in vivo. [Abstract]2024 Jun 14;14(1):13726. PMID: 38877189 -
Biomedicines
2023 Sep 27;11(10):2651. PMID: 37893024 -
J Biol Chem
Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide. [Abstract]2021 Jan-Jun:296:100807. PMID: 34022222 -
Cardiovasc Toxicol
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway. [Abstract]2023 Apr;23(3-4):161-175. PMID: 36934206 -
J Invest Surg
HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB. [Abstract]2022 May;35(5):1012-1020. PMID: 34670452 -
Microb Pathog
The active GLP-1 analogue liraglutide alleviates H9N2 influenza virus-induced acute lung injury in mice. [Abstract]2021 Jan;150:104645. PMID: 33285220 -
Mol Med Rep
Liraglutide attenuates the osteoblastic differentiation of MC3T3‑E1 cells by modulating AMPK/mTOR signaling. [Abstract]2016 Oct;14(4):3662-8. PMID: 27600753
Liraglutide acetate purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2016 Oct;14(4):3662-8. [Abstract]
Liraglutide (0-4 nM; 14 days). Relative protein expression of Alp and OC was analyzed by western blot and quantified relative to GAPDH.
-
Am J Physiol Renal Physiol
Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling. [Abstract]2020 Sep 1;319(3):F458-F468. PMID: 32715762
Liraglutide acetate purchased from MedChemExpress. Usage Cited in: Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F458-F468. [Abstract]
Representative Western blot showing FN protein abundance in HMCs cultured in media containing 5.5 mM glucose (NG) or 5.5 mM glucose + 19.5 mM mannitol (NG+M) or 25 mM glucose (HG) in the absence or presence of Liraglutide at different concentrations (1 nM, 10 nM, 100 nM, 1000 nM) for 24h.
-
J Biochem Mol Toxicol
The GLP-1 Receptor Agonist Liraglutide Promotes Anticancer Activities in MCF7 Breast and PC-3 Prostate Cancer Cells by Modulating Glycolysis, Oxidative Stress and Adipokines. [Abstract]2026 Jun;40(6):e70913. PMID: 42152582 -
Exp Biol Med
Glucagon-like peptide-1 receptor pathway inhibits extracellular matrix production by mesangial cells through store-operated Ca2+ channel. [Abstract]2019 Oct;244(14):1193-1201. PMID: 31510798 -
Clin Exp Pharmacol Physiol
GLP-1 receptor agonist liraglutide alleviates kidney injury by regulating nuclear translocation of NRF2 in diabetic nephropathy. [Abstract]2024 Dec;51(12):e70003. PMID: 39477212 -
Am J Physiol Regul Integr Comp Physiol
Liraglutide ameliorates inflammation and fibrosis by downregulating the TLR4/MyD88/NF-kappaB pathway in diabetic kidney disease. [Abstract]2024 Oct 1;327(4):R410-R422. PMID: 39133777 -
In Vitro Cell Dev Biol Anim
Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. [Abstract]2024 Oct;60(9):1046-1057. PMID: 39039329 -
-
-
bioRxiv
Unveiling the Hidden: Dissecting Liraglutide Oligomerization Dual Pathways via Direct Mass Technology, Electron-Capture Dissociation, and Molecular Dynamics. [Abstract]2025 Mar 4:2025.02.27.640645. PMID: 40093118 -
-
-
-
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)