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Cat. No.: HY-P11625

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R9-13

R9-13 is a fatty acid-conjugated relaxin and an agonist of LGR7 (RXFP1). R9-13 induces sustained pubic symphysis elongation in estrogen-pretreated mice. R9-13 exhibits long-acting pharmacokinetic profiles in rodents, with in vivo activity lasting up to one week after administration. R9-13 can be used in studies related to acute heart failure.

For research use only. We do not sell to patients.

Formula: C₂₉₄H₄₇₈N₇₈O₈₃S₉
Molecular Weight:6722.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

R9-13 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vivo

R9-13 (0.9-30 nmol/kg (30 μg/kg); single dose; administered via injection) exhibits a dose-dependent and sustained pubic ligament elongation (PLE) effect in estrogen-pretreated female CD1 mice, with an ED₅₀ of 5 nmol/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD1 (female; estrogen-primed)^[1]
Dosage:

0.9, 3.0, 9, 30 nmol/kg; 1, 10, 30 nmol/kg
Administration:

single dose; measured at 168 h after treatment
Result:

Observed dose-responsive pubic ligament elongation at 24 hours post-dosing; sustained elongation effect at 168 hours post-dosing.

Chemical Information

Molecular Weight 6722.00
Formula C₂₉₄H₄₇₈N₇₈O₈₃S₉
Sequence

Chain1:{pGln}-Cys(carbamic acid-PEG2-carbamic acid-PEG2-Lys-C18diacid)-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Ile-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys; Chain2:Ala-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser (Disulfidebridge:Chain 1 Cys10-Chain 1 Cys15,Chain 1 Cys11-Chain 2 Cys11,Chain 1 Cys24-Chain 2 Cys23
Sequence Shortening

Chain1:{pGln}-Cys(carbamic acid-PEG2-carbamic acid-PEG2-Lys-C18diacid)-YSALANKCCHVGCIKRSLARFC; Chain2:ASWMEEVIKLCGRELVRAQIAICGMSTWS (Disulfidebridge:Chain 1 Cys10-Chain 1 Cys15,Chain 1 Cys11-Chain 2 Cys11,Chain 1 Cys24-Chain 2 Cys23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Muppidi A, et al. Design and Synthesis of Potent, Long-Acting Lipidated Relaxin-2 Analogs. Bioconjug Chem. 2019;30(1):83-89. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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