2-(Phenylethynyl)-ATP ammonium
2-(Phenylethynyl)-ATP (ammonium) is a selective and potent GPR17 agonist with an EC50 of 35 pM. 2-(Phenylethynyl)-ATP (ammonium) also shows weak activation of P2Y Receptor. 2-(Phenylethynyl)-ATP (ammonium) can be used for the research of neurological disease.
For research use only. We do not sell to patients.
- CAS No.: 851191-73-6
- Formula: C18H32N9O13P3
- Molecular Weight:675.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All P2Y Receptor Isoforms
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Biological Activity
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GPR17 35 pM (EC50) |
P2Y12 Receptor 1348 nM (EC50) |
P2Y13 Receptor 3388 nM (EC50) |
P2Y14 Receptor 178 nM (EC50) |
2-(Phenylethynyl)-ATP (ammonium) (Compound 1) potently activates human GPR17 in transiently transfected HEK293 L9-2 cells, with an EC50 of 35 ± 3 pM[1].
2-(Phenylethynyl)-ATP (ammonium) activates human GPR17 in the [35S]GTPγS binding assay with an EC50 of 36 pM[1].
2-(Phenylethynyl)-ATP (ammonium) activates human P2Y12, P2Y13, and P2Y14 receptors in transiently transfected HEK293 L9-2 cells, with EC50 values of 178-3388 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 851191-73-6
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Molecular Weight 675.42
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Formula C18H32N9O13P3
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SMILES
O=P(OP(OP([O-])([O-])=O)([O-])=O)([O-])OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(N)N=C(C#CC4=CC=CC=C4)N=C32)O1.[NH4+].[NH4+].[NH4+].[NH4+]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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