GPR17 agonist 1

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GPR17 agonist 1 is a selective and potent GPR17 agonist with an EC₅₀ of 35 pM. GPR17 agonist 1 also shows weak activation of P2Y Receptor. GPR17 agonist 1 can be used for the research of neurological disease.

For research use only. We do not sell to patients.

GPR17 agonist 1 Chemical Structure

CAS No. : 851191-73-6

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Purity & Documentation
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Description

IC₅₀ & Target^[1]

GPR17

35 pM (EC₅₀)

P2Y12 Receptor

1348 nM (EC₅₀)

P2Y13 Receptor

3388 nM (EC₅₀)

P2Y14 Receptor

178 nM (EC₅₀)

In Vitro

GPR17 agonist 1 (Compound 1) potently activates human GPR17 in transiently transfected HEK293 L9-2 cells, with an EC₅₀ of 35 ± 3 pM^[1].
GPR17 agonist 1 activates human GPR17 in the [³⁵S]GTPγS binding assay with an EC₅₀ of 36 pM^[1].
GPR17 agonist 1 activates human P2Y₁₂, P2Y₁₃, and P2Y₁₄ receptors in transiently transfected HEK293 L9-2 cells, with EC₅₀ values of 178-3388 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

675.42

Formula

C₁₈H₃₂N₉O₁₃P₃

CAS No.

851191-73-6

SMILES

O=P(OP(OP([O-])([O-])=O)([O-])=O)([O-])OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(N)N=C(C#CC4=CC=CC=C4)N=C32)O1.[NH4+].[NH4+].[NH4+].[NH4+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dal Ben D, et al. Adenine nucleotides as potent and selective GPR17 modulators. Bioorg Chem. 2026;171:109567. [Content Brief]

GPR17 agonist 1 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR17 agonist 1851191-73-6Orphan GPCRP2Y ReceptorRrphan G protein-coupled receptorP2Y12P2Y13P2Y14Inhibitorinhibitorinhibit

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