Frizzled-5
Frizzled-5 (FZD5) signals chiefly through the canonical Wnt/beta-catenin route after its cysteine-rich domain binds ligands such as Wnt8b, partnering with LRP5 or LRP6 coreceptors. The receptor is essential for eye development: Fzd5-null mice develop coloboma, a failure of the optic fissure to close, and human FZD5 variants have been associated with microphthalmia and coloboma spectrum disorders. FZD5 is also expressed in vasculature, where it contributes to angiogenic remodeling, and in placenta, skin and reproductive tissues. In oncology, FZD5 upregulation has been observed in gastric, colorectal and pancreatic cancers, where it promotes proliferation and stem-like properties, positioning it as a candidate for antibody-based Wnt pathway intervention.
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Frizzled-5 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
