Frizzled-8
The FZD8 gene lies within the Williams-Beuren syndrome critical region on chromosome 7q11.23, and the receptor is hemizygously deleted in that disorder, suggesting a contribution to its neurodevelopmental and skeletal features. Frizzled-8 binds Wnt ligands through its cysteine-rich domain and activates both canonical beta-catenin signaling and planar cell polarity pathways. In bone biology, FZD8 modulates osteoblast differentiation and has been reported to enhance bone formation and protect against osteoporosis-related bone loss in animal studies. FZD8 expression is elevated in pancreatic cancer and in some breast tumor cell lines, where it supports Wnt-driven proliferation. Recombinant FZD8 CRD proteins are used as binding probes and as immunogens for antibody discovery against this receptor.
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Frizzled-8 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
