1. Vitamin D Related
  2. VD/VDR
  3. TEI-9647

TEI-9647 

Cat. No.: HY-12398
Handling Instructions

TEI-9647 is a first and potent VDR/vitamin D-responsive element (DRE)-mediated genomic actions antagonist. TEI-9647 is a 1α,25-dihydroxyvitamin D3-26,23-lactone (1α,25-lactone) analogue.

For research use only. We do not sell to patients.

TEI-9647 Chemical Structure

TEI-9647 Chemical Structure

CAS No. : 173388-20-0

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Description

TEI-9647 is a first and potent VDR/vitamin D-responsive element (DRE)-mediated genomic actions antagonist. TEI-9647 is a 1α,25-dihydroxyvitamin D3-26,23-lactone (1α,25-lactone) analogue[1].

IC50 & Target

VDR[1]

In Vitro

TEI-9647 (100 nM; 24 hours; HL-60 cells) treatment clearly suppresses p21WAF1,CIP1 gene expression induced by 1α,25(OH)2D3[1].
TEI-9647 blocks both 1α,25(OH)2D3-mediated HL-60 cell differentiation and also activation of the luciferase reporter in COS-7 cells that has been transfected with the cDNA containing the DRE of the rat 25(OH)D3-24-hydroxylase gene and cDNA of the human vitamin D nuclear receptor[1].

RT-PCR[1]

Cell Line: HL-60 cells
Concentration: 100 nM
Incubation Time: 24 hours
Result: Clearly suppressed p21WAF1,CIP1 gene expression induced by 1α,25(OH)2D3.
Molecular Weight

426.59

Formula

C₂₇H₃₈O₄

CAS No.

173388-20-0

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Keywords:

TEI-9647TEI9647TEI 9647VD/VDRVitamin DVitamin D receptorp21differentiationcDNADREvitamin-DgenomicInhibitorinhibitorinhibit

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