1. Vitamin D Related
  2. VD/VDR
  3. TEI-9648

TEI-9648 

Cat. No.: HY-12398A
Handling Instructions

TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research.

For research use only. We do not sell to patients.

TEI-9648 Chemical Structure

TEI-9648 Chemical Structure

CAS No. : 173388-21-1

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1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2].

In Vitro

TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1].
TEI-9648 has consistently weaker suppressive effect than TEI-9647[1].
TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell[1].
TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)2D3 (0.1 nM) in HL-60 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

426.59

Formula

C₂₇H₃₈O₄

CAS No.

173388-21-1

SMILES
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Keywords:

TEI-9648TEI9648TEI 9648VD/VDRVitamin DVitamin D receptorVitaminD31α,25-(OH)2D3bonemetabolismCD11bCD71HL-60differentiationInhibitorinhibitorinhibit

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TEI-9648
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