7054-25-3
Chemical Structure
Quinidine gluconic acid
- CAS No.: 7054-25-3
- Formula:C26H36N2O9
- Molecular Weight:520.57
IUPAC Name: (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
InChIKey: XHKUDCCTVQUHJQ-LCYSNFERSA-N
SMILES: C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
Biological Activity: Quinidine gluconic acid is an orally effective antiarrhythmic agent. Quinidine gluconic acid blocks the fast inward sodium current in a use-dependent manner, blocks IKr in a reverse use-dependent manner, and blocks the ultra-rapid delayed rectifier potassium current with an EC50 of 6.2 μM, while also inhibiting CYP2D6 and P-gp. Quinidine gluconic acid induces PARP cleavage, Caspase-3 activation, and increases the proportion of sub-G1 phase apoptotic (Apoptotic) cells. Quinidine gluconic acid can be used in research on ischemia/reperfusion-induced cardiac injury, drug-resistant leukemia, convulsions, and uterine sarcoma[1][2][3][4][5].
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Quinidine gluconic acid | Quinidine gluconic acid is an orally effective antiarrhythmic agent. Quinidine gluconic acid blocks the fast inward sodium current in a use-dependent manner, blocks IKr in a reverse use-dependent manner, and blocks the ultra-rapid delayed rectifier potassium current with an EC50 of 6.2 μM, while also inhibiting CYP2D6 and P-gp. Quinidine gluconic acid induces PARP cleavage, Caspase-3 activation, and increases the proportion of sub-G1 phase apoptotic (Apoptotic) cells. Quinidine gluconic acid can be used in research on ischemia/reperfusion-induced cardiac injury, drug-resistant leukemia, convulsions, and uterine sarcoma. | |||||||||||||||||||||
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References
- [1]. Lee SY, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environmental toxicology. 2011 Aug;26(4):424-31. [Content Brief]
- [2]. Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13. [Content Brief]
- [3]. Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14(5):311-7. [Content Brief]
- [4]. Jamali H, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988. [Content Brief]
- [5]. Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide. [Content Brief]
