PGP/FSP1-IN-1
PGP/FSP1-IN-1 is a dual PGP and FSP1 inhibitor and ferroptosis inducer that inhibits the oxidoreductase activity of FSP1. PGP/FSP1-IN-1 competes with NAD (P) H for binding to the pocket of FSP1 and induces FSP1 self-assembly, thereby directly blocking the catalytic function of the relevant enzyme. PGP/FSP1-IN-1 promotes lipid peroxidation and significantly enhances cellular sensitivity to ferroptosis when GPX4 activity is impaired or glutathione synthesis is inhibited. PGP/FSP1-IN-1 can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 328265-32-3
- Formula: C28H20N2O7
- Molecular Weight:496.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PGP/FSP1-IN-1 (Compound 1) (50 μM) competes with NADH for binding to recombinant purified murine FSP1, as saturating PGP/FSP1-IN-1 completely blocks detectable NADH binding to mFSP1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 328265-32-3
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Molecular Weight 496.47
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Formula C28H20N2O7
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SMILES
O=C(C1=CC=CC=C1NC(C2=CC=C(C=C2)OC3=CC=C(C=C3)C(NC4=C(C=CC=C4)C(O)=O)=O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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