328265-32-3
Chemical Structure
PGP/FSP1-IN-1
- CAS No.: 328265-32-3
- Formula:C28H20N2O7
- Molecular Weight:496.47
InChIKey: UIRNMCRFFYWCBB-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1NC(C2=CC=C(C=C2)OC3=CC=C(C=C3)C(NC4=C(C=CC=C4)C(O)=O)=O)=O)O
Biological Activity: PGP/FSP1-IN-1 is a dual PGP and FSP1 inhibitor and ferroptosis inducer that inhibits the oxidoreductase activity of FSP1. PGP/FSP1-IN-1 competes with NAD (P) H for binding to the pocket of FSP1 and induces FSP1 self-assembly, thereby directly blocking the catalytic function of the relevant enzyme. PGP/FSP1-IN-1 promotes lipid peroxidation and significantly enhances cellular sensitivity to ferroptosis when GPX4 activity is impaired or glutathione synthesis is inhibited. PGP/FSP1-IN-1 can be used in cancer research[1].
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PGP/FSP1-IN-1 | PGP/FSP1-IN-1 is a dual PGP and FSP1 inhibitor and ferroptosis inducer that inhibits the oxidoreductase activity of FSP1. PGP/FSP1-IN-1 competes with NAD (P) H for binding to the pocket of FSP1 and induces FSP1 self-assembly, thereby directly blocking the catalytic function of the relevant enzyme. PGP/FSP1-IN-1 promotes lipid peroxidation and significantly enhances cellular sensitivity to ferroptosis when GPX4 activity is impaired or glutathione synthesis is inhibited. PGP/FSP1-IN-1 can be used in cancer research. | |||||||||||||||||||||
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