Catechin-5-O-gallate 

Catechin-5-O-gallate is a bioactive substance. Catechin-5-O-gallate can be isolated from bioactive Himalayan plants. Catechin-5-O-gallate is predicted to be a P-glycoprotein inhibitor, and binds to SARS-CoV-2 3CLpro, PLpro and RdRp. Catechin-5-O-gallate can be used in studies related to COVID-19^[1].

Catechin-5-O-gallate binds to the active site of SARS-CoV-2 3CLpro (PDB ID: 6LU7) with a binding energy of -8.2 kcal/mol and a K_i of 0.99 μM, indicating its potential inhibitory activity against this viral protease^[1].
Catechin-5-O-gallate binds to the active site of SARS-CoV-2 PLpro (PDB ID: 7JRN) with a binding energy of -7.1 kcal/mol and a K_i of 6.34 μM, indicating its potential inhibitory activity against this viral protease^[1].
Catechin-5-O-gallate binds to the active site of SARS-CoV-2 RdRp (PDB ID: 6M71) with a binding energy of -8.0 kcal/mol and a K_i of 1.39 μM, indicating that it has potential inhibitory activity against this viral polymerase^[1].
Catechin-5-O-gallate binds to the ATP-binding site of SARS-CoV-2 helicase (PDB ID: 6ZSL) with a binding energy of -8.7 kcal/mol and a K_i of 0.43 μM, indicating its potential inhibitory activity against this viral enzyme^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

442.37

C₂₂H₁₈O₁₀

128232-62-2

O=C(C1=CC(O)=C(C(O)=C1)O)OC2=C3C(O[C@H](C4=CC(O)=C(C=C4)O)[C@H](C3)O)=CC(O)=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Natesh J, et al. Promising phytochemicals of traditional Himalayan medicinal plants against putative replication and transmission targets of SARS-CoV-2 by computational investigation. Comput Biol Med. 2021;133:104383.