115103-85-0
Chemical Structure
MK-571 sodium
Synonym(s): L-660711 sodium
- CAS No.: 115103-85-0
- Formula:C26H26ClN2NaO3S2
- Molecular Weight:537.07
IUPAC Name: sodium (E)-3-(((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propanoate
InChIKey: XNAYQOBPAXEYLI-AAGWESIMSA-M
SMILES: O=C(O[Na])CCSC(C1=CC=CC(/C=C/C2=NC3=CC(Cl)=CC=C3C=C2)=C1)SCCC(N(C)C)=O
Biological Activity: MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MK-571 sodium | 99.75% | MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release. | ||||||||||||||||||||
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Similarity Score 0.92
HY-19989MK-571 -
Similarity Score 0.92
HY-76511Verlukast -
Similarity Score 0.79
HY-76511SVerlukast-d6 -
Similarity Score 0.58
HY-13315Montelukast sodium -
Similarity Score 0.58
HY-Z8531Montelukast impurity 2 sodium -
Similarity Score 0.57
HY-Z4504Montelukast impurity 7 -
Similarity Score 0.57
HY-105426L-695499 -
Similarity Score 0.57
HY-W707814Montelukast impurity 1 hydrochloride -
Similarity Score 0.56
HY-Z4506Montelukast impurity 1 -
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References
- [1]. Jones TR, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28. [Content Brief]
- [2]. Hara Y, et al. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest. 2011 Jul;121(7):2888-97. [Content Brief]
- [3]. Mitra P, et al. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9. [Content Brief]
