Lys-(Des-Arg9,Leu8)-Bradykinin
Based on 1 Customer Validation
Lys-(Des-Arg9,Leu8)-Bradykinin is a selective bradykinin B1 receptor (BDKRB1) antagonist. Lys-(Des-Arg9,Leu8)-Bradykinin inhibits local inflammatory edema. Lys-(Des-Arg9,Leu8)-Bradykinin induces the production of systemic acute-phase proteins. Lys-(Des-Arg9,Leu8)-Bradykinin is applicable to research related to peptidoglycan-polysaccharide-induced acute arthritis.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 71800-37-8
- Formula: C47H75N13O11
- Molecular Weight:998.18
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-P0206
Bradykinin
-
HY-17446
Icatibant
-
HY-P1469
Bradykinin (1-6)
-
HY-108896
Icatibant acetate
-
HY-105155
Lobradimil
-
HY-15039
SSR240612
-
HY-P1490
Bradykinin (2-9)
-
HY-15043
ELN-441958
-
HY-P1488
Bradykinin (1-5)
-
![Sar-[D-Phe8]-des-Arg9-Bradykinin](https://file.medchemexpress.com/product_pic/hy-103291.gif)
HY-103291
Sar-[D-Phe8]-des-Arg9-Bradykinin
-
![[Hyp3]-Bradykinin](https://file.medchemexpress.com/product_pic/hy-p3061.gif)
HY-P3061
[Hyp3]-Bradykinin
-
HY-P1484
Bradykinin (1-7)
All Bradykinin Receptor Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.99 μM
Compound: DALK(BA)
|
Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay
Antagonist activity against bradykinin B1 receptor in human HeLa cells assessed as inhibition of Des-Arg9-BK-induced increase in intracellular Ca2+ level by Fluro-4 direct calcium dye based fluorescence assay
|
[PMID: 27977181] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 71800-37-8
-
Appearance Solid
-
Molecular Weight 998.18
-
Formula C47H75N13O11
-
Color White to off-white
-
Sequence
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu
-
Sequence Shortening
KRPPGFSPL
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (50.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (278 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0018 mL | 5.0091 mL | 10.0182 mL | 25.0456 mL |
| 5 mM | 0.2004 mL | 1.0018 mL | 2.0036 mL | 5.0091 mL | |
| 10 mM | 0.1002 mL | 0.5009 mL | 1.0018 mL | 2.5046 mL | |
| 15 mM | 0.0668 mL | 0.3339 mL | 0.6679 mL | 1.6697 mL | |
| 20 mM | 0.0501 mL | 0.2505 mL | 0.5009 mL | 1.2523 mL | |
| 25 mM | 0.0401 mL | 0.2004 mL | 0.4007 mL | 1.0018 mL | |
| 30 mM | 0.0334 mL | 0.1670 mL | 0.3339 mL | 0.8349 mL | |
| 40 mM | 0.0250 mL | 0.1252 mL | 0.2505 mL | 0.6261 mL | |
| 50 mM | 0.0200 mL | 0.1002 mL | 0.2004 mL | 0.5009 mL |
Lys-(Des-Arg9,Leu8)-Bradykinin Related Classifications
HY-P4676 Related Classifications
Powered by Bioz