1. GPCR/G Protein
  2. Bradykinin Receptor
  3. Icatibant

Icatibant (Synonyms: HOE 140)

Cat. No.: HY-17446 Purity: 99.51%
Handling Instructions

Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.

For research use only. We do not sell to patients.

Icatibant Chemical Structure

Icatibant Chemical Structure

CAS No. : 130308-48-4

Size Price Stock Quantity
10 mM * 1  mL in Water USD 1119 In-stock
Estimated Time of Arrival: December 31
1 mg USD 270 In-stock
Estimated Time of Arrival: December 31
5 mg USD 540 In-stock
Estimated Time of Arrival: December 31
10 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Icatibant:

Top Publications Citing Use of Products
  • Biological Activity

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Description

Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3].

In Vitro

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

In Vivo

Icatibant (0.3, or 1.5 mg/kg, subcutaneous administration twice daily in mice) shows a significant preventive effect on ulcerative Colitis[2].

Animal Model: Female mice of the CBA/J (H-2k) strain[2].
Dosage: 0.06, 0.3, or 1.5 mg/kg.
Administration: Subcutaneous administration twice daily.
Result: The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.
Clinical Trial
Molecular Weight

1304.52

Formula

C₅₉H₈₉N₁₉O₁₃S

CAS No.

130308-48-4

SMILES

[H][[email protected]]1(C[[email protected]@H](C(N[[email protected]](C(O)=O)CCCNC(N)=N)=O)N2C([[email protected]@H]3N(C([[email protected]](CO)NC([[email protected]](CC4=CC=CS4)NC(CNC([[email protected]@H]5C[[email protected]@H](O)CN5C([[email protected]]6N(C([[email protected]](CCCNC(N)=N)NC([[email protected]](N)CCCNC(N)=N)=O)=O)CCC6)=O)=O)=O)=O)=O)CC7=C(C=CC=C7)C3)=O)[[email protected]]2([H])CCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (38.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7666 mL 3.8328 mL 7.6657 mL
5 mM 0.1533 mL 0.7666 mL 1.5331 mL
10 mM 0.0767 mL 0.3833 mL 0.7666 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.51%

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Keywords:

IcatibantHOE 140HOE140HOE-140Bradykinin ReceptorangiotensinulcerativecolitisInhibitorinhibitorinhibit

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Icatibant
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