1. GPCR/G Protein
  2. Bradykinin Receptor
  3. Icatibant acetate

Icatibant acetate (Synonyms: HOE 140 acetate)

Cat. No.: HY-108896 Purity: 99.64%
Handling Instructions

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Icatibant acetate Chemical Structure

Icatibant acetate Chemical Structure

CAS No. : 138614-30-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1051 In-stock
Estimated Time of Arrival: December 31
1 mg USD 115 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3].

In Vitro

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female mice of the CBA/J (H-2k) strain[2].
Dosage: 0.06, 0.3, or 1.5 mg/kg.
Administration: Subcutaneous administration twice daily.
Result: The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.
Molecular Weight

1364.57

Formula

C₆₁H₉₃N₁₉O₁₅S

CAS No.

138614-30-9

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Protect from light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (73.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7328 mL 3.6642 mL 7.3283 mL
5 mM 0.1466 mL 0.7328 mL 1.4657 mL
10 mM 0.0733 mL 0.3664 mL 0.7328 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

IcatibantHOE 140HOE140HOE-140Bradykinin ReceptorulcerativecolitisangiotensinInhibitorinhibitorinhibit

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Product Name:
Icatibant acetate
Cat. No.:
HY-108896
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