2. GPCR/G Protein
  3. Bradykinin Receptor
  4. Icatibant acetate

Icatibant acetate  (Synonyms: HOE 140 acetate)

Cat. No.: HY-108896 Purity: 99.65%
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Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively.

For research use only. We do not sell to patients.

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Icatibant acetate Chemical Structure

Icatibant acetate Chemical Structure

CAS No. : 138614-30-9

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1 mg USD 80 In-stock
5 mg USD 240 In-stock
10 mg USD 380 In-stock
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Based on 8 publication(s) in Google Scholar

Other Forms of Icatibant acetate:

Icatibant acetate Related Antibodies

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3].

In Vitro

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Icatibant acetate Related Antibodies
In Vivo

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female mice of the CBA/J (H-2k) strain[2].
Dosage: 0.06, 0.3, or 1.5 mg/kg.
Administration: Subcutaneous administration twice daily.
Result: The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.
Clinical Trial
Molecular Weight

1364.57

Formula

C61H93N19O15S
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (73.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7328 mL 3.6642 mL 7.3283 mL
5 mM 0.1466 mL 0.7328 mL 1.4657 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7328 mL 3.6642 mL 7.3283 mL 18.3208 mL
5 mM 0.1466 mL 0.7328 mL 1.4657 mL 3.6642 mL
10 mM 0.0733 mL 0.3664 mL 0.7328 mL 1.8321 mL
15 mM 0.0489 mL 0.2443 mL 0.4886 mL 1.2214 mL
20 mM 0.0366 mL 0.1832 mL 0.3664 mL 0.9160 mL
25 mM 0.0293 mL 0.1466 mL 0.2931 mL 0.7328 mL
30 mM 0.0244 mL 0.1221 mL 0.2443 mL 0.6107 mL
40 mM 0.0183 mL 0.0916 mL 0.1832 mL 0.4580 mL
50 mM 0.0147 mL 0.0733 mL 0.1466 mL 0.3664 mL
60 mM 0.0122 mL 0.0611 mL 0.1221 mL 0.3053 mL
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Icatibant acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Icatibant138614-30-9HOE 140HOE140HOE-140Bradykinin ReceptorulcerativecolitisangiotensinInhibitorinhibitorinhibit

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