2. GPCR/G Protein
  3. Bradykinin Receptor
  4. Icatibant acetate

Icatibant acetate  (Synonyms: HOE 140 acetate)

Cat. No.: HY-108896 Purity: 99.74%
COA Handling Instructions

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively.

For research use only. We do not sell to patients.

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Icatibant acetate Chemical Structure

Icatibant acetate Chemical Structure

CAS No. : 138614-30-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 1051 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 1051 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 115 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Icatibant acetate:

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Description

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3].

In Vitro

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female mice of the CBA/J (H-2k) strain[2].
Dosage: 0.06, 0.3, or 1.5 mg/kg.
Administration: Subcutaneous administration twice daily.
Result: The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.
Clinical Trial
Molecular Weight

1364.57

Appearance

Solid

Formula

C61H93N19O15S
CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (73.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7328 mL 3.6642 mL 7.3283 mL
5 mM 0.1466 mL 0.7328 mL 1.4657 mL
10 mM 0.0733 mL 0.3664 mL 0.7328 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Icatibant138614-30-9HOE 140HOE140HOE-140Bradykinin ReceptorulcerativecolitisangiotensinInhibitorinhibitorinhibit

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