1. GPCR/G Protein
  2. Bradykinin Receptor
  3. Icatibant acetate

Icatibant acetate (Synonyms: HOE 140 acetate)

Cat. No.: HY-108896
Handling Instructions

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.

For research use only. We do not sell to patients.

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Icatibant acetate Chemical Structure

Icatibant acetate Chemical Structure

CAS No. : 138614-30-9

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Description

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3].

In Vitro

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

In Vivo

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3].

Animal Model: Female mice of the CBA/J (H-2k) strain[2].
Dosage: 0.06, 0.3, or 1.5 mg/kg.
Administration: Subcutaneous administration twice daily.
Result: The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.
Molecular Weight

1364.57

Formula

C₆₁H₉₃N₁₉O₁₅S

CAS No.

138614-30-9

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IcatibantHOE 140HOE140HOE-140Bradykinin ReceptorulcerativecolitisangiotensinInhibitorinhibitorinhibit

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Icatibant acetate
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