Icatibant acetate (Synonyms: HOE 140 acetate)

Name: Icatibant acetate
Brand: MedChemExpress
SKU: HY-108896
Rating: 5.0 (12 reviews)

Cat. No.: HY-108896 Purity: 99.87%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC₅₀ and K_i of 1.07 nM and 0.798 nM respectively.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 138614-30-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Icatibant acetate:

Icatibant In-stock
Icatibant acetate (Standard) Get quote

12 Publications Citing Use of MCE Icatibant acetate

ELISA

Bio/Physico-chemical Assay

RT-PCR

Histological Imaging/Staining

In Vivo Efficacy Study

: Icatibant acetate purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2024 Oct;181(19):3760-3778. [Abstract]; Icatibant (1.5 mg/kg; i.p.; every 12 h) treatment reduced plasma levels of TNF-α and IL-1β in the psoriatic mice.

: Icatibant acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]; Icatibant (1 mg/kg; i.p.; 3 h) significantly downregulated UCP1 in the BAT of C57BL/6J mice exposed to acute cold.

: Icatibant acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]; Icatibant (1 mg/kg; i.p.; 3 h) markedly reduced mRNA levels of browning marker genes in the sWAT of C57BL/6J mice exposed to acute cold.

: Icatibant acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]; Icatibant (1 mg/kg; i.p.; 3 h) enlarged lipid droplets in the sWAT of C57BL/6J mice exposed to acute cold.

: Icatibant acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]; Icatibant (1 mg/kg; i.p.; 3 h) reduced body temperature of C57BL/6J mice during acute cold exposure.

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

Biological Activity
Purity & Documentation
References
Customer Review

Description

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC₅₀ and K_i of 1.07 nM and 0.798 nM respectively^[1]^[2]^[3].

IC₅₀ & Target

Bradykinin B2 Receptor (B2R)

In Vivo

Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female mice of the CBA/J (H-2^k) strain^[2].
Dosage:	0.06, 0.3, or 1.5 mg/kg.
Administration:	Subcutaneous administration twice daily.
Result:	The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.

Clinical Trial

Molecular Weight

1364.57

Formula

C₆₁H₉₃N₁₉O₁₅S

CAS No.

138614-30-9

Appearance

Solid

Color

White to off-white

Sequence

Asp-Arg-Arg-Pro-Hyp-Gly-Thia-Thr-Thr-Arg-Asp-Phe-Ile-Glu-Ile-Ile-Trp-Arg-Lys-NH2

Sequence Shortening

DRRP-Hyp-G-Thia-TTREDFIIWRK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (73.28 mM; Need ultrasonic)

DMSO : 100 mg/mL (73.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7328 mL	3.6642 mL	7.3283 mL
5 mM	0.1466 mL	0.7328 mL	1.4657 mL
10 mM	0.0733 mL	0.3664 mL	0.7328 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: ≥ 100 mg/mL (73.28 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (278 KB) SDS (254 KB)

COA (252 KB) RP-HPLC (223 KB) MS (191 KB)

Handling Instructions (2659 KB)

References

[1]. Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73. [Content Brief]

[2]. Y Arai, et al. Effect of Icatibant, a Bradykinin B2 Receptor Antagonist, on the Development of Experimental Ulcerative Colitis in Mice. Dig Dis Sci. 1999 Apr;44(4):845-51. [Content Brief]

[3]. Marie-Thérèse Bawolak, et al The Bradykinin B2 Receptor Antagonist Icatibant (Hoe 140) Blocks Aminopeptidase N at Micromolar Concentrations: Off-Target Alterations of Signaling Mediated by the Bradykinin B1 and Angiotensin Receptors. Eur J Pharmacol. 2006 Dec 3;551(1-3):108-11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.7328 mL	3.6642 mL	7.3283 mL	18.3208 mL
	5 mM	0.1466 mL	0.7328 mL	1.4657 mL	3.6642 mL
	10 mM	0.0733 mL	0.3664 mL	0.7328 mL	1.8321 mL
	15 mM	0.0489 mL	0.2443 mL	0.4886 mL	1.2214 mL
	20 mM	0.0366 mL	0.1832 mL	0.3664 mL	0.9160 mL
	25 mM	0.0293 mL	0.1466 mL	0.2931 mL	0.7328 mL
	30 mM	0.0244 mL	0.1221 mL	0.2443 mL	0.6107 mL
	40 mM	0.0183 mL	0.0916 mL	0.1832 mL	0.4580 mL
	50 mM	0.0147 mL	0.0733 mL	0.1466 mL	0.3664 mL
	60 mM	0.0122 mL	0.0611 mL	0.1221 mL	0.3053 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Icatibant acetate Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Icatibant138614-30-9HOE 140HOE140HOE-140Bradykinin ReceptorulcerativecolitisangiotensinInhibitorinhibitorinhibit

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Icatibant acetate (Synonyms: HOE 140 acetate)

Customer Review

Other Forms of Icatibant acetate:

Icatibant acetate Related Antibodies

12 Publications Citing Use of MCE Icatibant acetate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Bradykinin Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Icatibant acetate Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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