209788-45-4
Chemical Structure
Anatibant hydrochloride
Synonym(s): LF 16-0687 hydrochloride; XY-2405 hydrochloride
- CAS No.: 209788-45-4
- Formula:C34H38Cl4N6O5S
- Molecular Weight:784.58
InChIKey: CTFZQFRXSBZMTH-LPCSYZHESA-N
SMILES: O=C(NCCCNC(C1=CC=C(C=C1)C(N)=N)=O)[C@H]2N(CCC2)S(=O)(C3=CC=C(C(COC4=C5N=C(C=C(C5=CC=C4)C)C)=C3Cl)Cl)=O.Cl.Cl
Biological Activity: Anatibant hydrochloride (LF 16-0687 hydrochloride; XY-2405 hydrochloride) is a selective non-peptide bradykinin B2 receptor antagonist. Anatibant hydrochloride binds to the human, rat and guinea-pig recombinant B2 receptor with Ki values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant hydrochloride crosses the blood-brain barrier (BBB). Anatibant hydrochloride can be used in research on brain damage diseases[1][2].
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Anatibant hydrochloride | 99.44% | Anatibant hydrochloride (LF 16-0687 hydrochloride; XY-2405 hydrochloride) is a selective non-peptide bradykinin B2 receptor antagonist. Anatibant hydrochloride binds to the human, rat and guinea-pig recombinant B2 receptor with Ki values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant hydrochloride crosses the blood-brain barrier (BBB). Anatibant hydrochloride can be used in research on brain damage diseases. | ||||||||||||||||||||
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References
- [1]. Klaus Zweckberger, et al. Anatibant, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury. Neurosci Lett. 2009 Apr 24;454(2):115-7. [Content Brief]
- [2]. D Pruneau, et al. Pharmacological profile of LF 16-0687, a new potent non-peptide bradykinin B2 receptor antagonist. Immunopharmacology. 1999 Sep;43(2-3):187-94. [Content Brief]
