2763588-90-3
![Lys-[Des-Arg9]Bradykinin TFA Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-103295a.gif "Lys-[Des-Arg9]Bradykinin TFA Chemical Structure")
Chemical Structure
Lys-[Des-Arg9]Bradykinin TFA
- CAS No.: 2763588-90-3
- Formula:C52H74F3N13O13
- Molecular Weight:1146.22
IUPAC Name: L-lysyl-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanine compound with 2,2,2-trifluoroacetic acid (1:1)
InChIKey: BUNFBEBTCVIRNN-HVJIRRSLSA-N
SMILES: O=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@@H](N)CCCCN)=O)=O)N2[C@@H](CCC2)C(NCC(N[C@H](C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O.OC(C(F)(F)F)=O
Biological Activity: Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors[1][2].
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Lys-[Des-Arg9]Bradykinin TFA | 99.31% | Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors. | ||||||||||||||||||||
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- [1]. Rosalind Gulliver, et al. Lys-des[Arg9]-bradykinin alters migration and production of interleukin-12 in monocyte-derived dendritic cells. Am J Respir Cell Mol Biol. 2011 Sep;45(3):542-9. [Content Brief]
- [2]. L M Fredrik Leeb-Lundberg, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. [Content Brief]
Keywords
