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Art. -Nr.: HY-P0298

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[Des-Arg9]-Bradykinin

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[Des-Arg9]-Bradykinin is a Bradykinin (B₁) receptor agonist that displays selectivity for B₁ over B₂ receptors.

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CAS. Nr.: 15958-92-6
Formel: C₄₄H₆₁N₁₁O₁₀
Molecular Weight:904.02

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[Des-Arg9]-Bradykinin Chemical Structure

CAS. Nr.: 15958-92-6

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Biologische Aktivität

Beschreibung

[Des-Arg9]-Bradykinin is a Bradykinin (B₁) receptor agonist that displays selectivity for B₁ over B₂ receptors.

IC₅₀ & Target

Bradykinin B1 Receptor (B1R)

Alle Bradykinin Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

The B₂ receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins, whereas the B₁ receptor mediates the action of [Des-Arg⁹]-Bradykinin (des-Arg⁹-BK) and Lys-des-Arg Arg⁹-BK, the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 15958-92-6
Molecular Weight 904.02
Formel C₄₄H₆₁N₁₁O₁₀
Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe
Sequence Shortening

RPPGFSPF
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Nat Commun

Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice. [Abstract]

2023 Sep 21;14(1):5891. PMID: 37735515

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Leeb-Lundberg LM, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. [Content Brief]

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Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

[Des-Arg9]-Bradykinin

1 Cited Publications

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[Des-Arg9]-Bradykinin

Publications Citing Use of MedChemExpress (MCE) [Des-Arg9]-Bradykinin

Alle Bradykinin Receptor Isoform-spezifische Produkte anzeigen

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[Des-Arg9]-Bradykinin Related Classifications

HY-P0298 Related Classifications