[Des-Arg9]-Bradykinin acetate

Name: [Des-Arg9]-Bradykinin acetate
Brand: MedChemExpress
SKU: HY-P0298A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P0298A Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

[Des-Arg9]-Bradykinin acetate is a Bradykinin B₁ receptor agonist that displays selectivity for B₁ over B₂ receptors.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Des-Arg9]-Bradykinin acetate Chemical Structure

CAS No. : 23827-91-0

Size	Price	Stock	Quantity
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 96	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 216	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of [Des-Arg9]-Bradykinin acetate:

[Des-Arg9]-Bradykinin Get quote

1 Publications Citing Use of MCE [Des-Arg9]-Bradykinin acetate

•Nat Commun. 2023 Sep 21;14(1):5891. [Abstract]

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

Biological Activity
Purity & Documentation
References
Customer Review

Description

[Des-Arg9]-Bradykinin acetate is a Bradykinin B₁ receptor agonist that displays selectivity for B₁ over B₂ receptors.

IC₅₀ & Target

Bradykinin B₁ receptor^[1]

In Vitro

[Des-Arg9]-Bradykinin acetate is a Bradykinin(B₁) receptor agonist. The B₂ receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins, whereas the B₁ receptor mediates the action of [Des-Arg⁹]-Bradykinin (des-Arg⁹-BK) and Lys-des-Arg Arg⁹-BK, the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

964.07

Formula

C₄₆H₆₅N₁₁O₁₂

CAS No.

23827-91-0

Appearance

Solid

Color

White to off-white

Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe

Sequence Shortening

RPPGFSPF

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (103.73 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0373 mL	5.1863 mL	10.3727 mL
5 mM	0.2075 mL	1.0373 mL	2.0745 mL
10 mM	0.1037 mL	0.5186 mL	1.0373 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: ≥ 100 mg/mL (103.73 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (282 KB) SDS (252 KB)

COA (264 KB) LCMS (250 KB) Elemental Analysis Report (124 KB)

Handling Instructions (2659 KB)

References

[1]. Leeb-Lundberg LM, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0373 mL	5.1863 mL	10.3727 mL	25.9317 mL
	5 mM	0.2075 mL	1.0373 mL	2.0745 mL	5.1863 mL
	10 mM	0.1037 mL	0.5186 mL	1.0373 mL	2.5932 mL
	15 mM	0.0692 mL	0.3458 mL	0.6915 mL	1.7288 mL
	20 mM	0.0519 mL	0.2593 mL	0.5186 mL	1.2966 mL
	25 mM	0.0415 mL	0.2075 mL	0.4149 mL	1.0373 mL
	30 mM	0.0346 mL	0.1729 mL	0.3458 mL	0.8644 mL
	40 mM	0.0259 mL	0.1297 mL	0.2593 mL	0.6483 mL
	50 mM	0.0207 mL	0.1037 mL	0.2075 mL	0.5186 mL
	60 mM	0.0173 mL	0.0864 mL	0.1729 mL	0.4322 mL
	80 mM	0.0130 mL	0.0648 mL	0.1297 mL	0.3241 mL
	100 mM	0.0104 mL	0.0519 mL	0.1037 mL	0.2593 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.