[Des-Arg9]-Bradykinin acetate
Based on 1 publication(s) in Google Scholar
[Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 23827-91-0
- Formula: C46H65N11O12
- Molecular Weight:964.07
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
![[Des-Arg9]-Bradykinin acetate Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p0298a.gif "Click to View [Des-Arg9]-Bradykinin acetate Chemical Structure")
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) [Des-Arg9]-Bradykinin acetate
MoreAll Bradykinin Receptor Isoforms
More
Biological Activity
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Bradykinin B1 Receptor (B1R) |
[Des-Arg9]-Bradykinin acetate is a Bradykinin(B1) receptor agonist. The B2 receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins, whereas the B1 receptor mediates the action of [Des-Arg9]-Bradykinin (des-Arg9-BK) and Lys-des-Arg Arg9-BK, the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 23827-91-0
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Appearance Solid
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Molecular Weight 964.07
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Formula C46H65N11O12
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Color White to off-white
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Sequence
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe
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Sequence Shortening
RPPGFSPF
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice. [Abstract]2023 Sep 21;14(1):5891. PMID: 37735515
Solvent & Solubility
H2O : 100 mg/mL (103.73 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: ≥ 100 mg/mL (103.73 mM); Clear solution
Purity & Documentation
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0373 mL | 5.1863 mL | 10.3727 mL | 25.9317 mL |
| 5 mM | 0.2075 mL | 1.0373 mL | 2.0745 mL | 5.1863 mL | |
| 10 mM | 0.1037 mL | 0.5186 mL | 1.0373 mL | 2.5932 mL | |
| 15 mM | 0.0692 mL | 0.3458 mL | 0.6915 mL | 1.7288 mL | |
| 20 mM | 0.0519 mL | 0.2593 mL | 0.5186 mL | 1.2966 mL | |
| 25 mM | 0.0415 mL | 0.2075 mL | 0.4149 mL | 1.0373 mL | |
| 30 mM | 0.0346 mL | 0.1729 mL | 0.3458 mL | 0.8644 mL | |
| 40 mM | 0.0259 mL | 0.1297 mL | 0.2593 mL | 0.6483 mL | |
| 50 mM | 0.0207 mL | 0.1037 mL | 0.2075 mL | 0.5186 mL | |
| 60 mM | 0.0173 mL | 0.0864 mL | 0.1729 mL | 0.4322 mL | |
| 80 mM | 0.0130 mL | 0.0648 mL | 0.1297 mL | 0.3241 mL | |
| 100 mM | 0.0104 mL | 0.0519 mL | 0.1037 mL | 0.2593 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
[Des-Arg9]-Bradykinin acetate Related Classifications
HY-P0298A Related Classifications
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