PI4KB Protein, Human (Sf9, His, GST)

The PI4KB protein is a key enzyme that initiates the production of 1,4,5-trisphosphate inositol (PIP) by phosphorylating phosphatidylinositol (PI). In addition to myo-inositol signaling, it is involved in mitotic Golgi disassembly and Golgi-to-plasma membrane trafficking, which is critical for cell membrane dynamics. PI4KB Protein, Human (Sf9, His, GST) is the recombinant human-derived PI4KB protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of PI4KB Protein, Human (Sf9, His, GST) is 815 a.a., .

PI4KB, a pivotal enzyme, phosphorylates phosphatidylinositol (PI), initiating the crucial step in generating the second messenger inositol-1,4,5-trisphosphate (PIP). Beyond its fundamental role in inositol signaling, PI4KB is implicated in Golgi disintegration/reorganization during mitosis, possibly through its phosphorylation. Additionally, it participates in Golgi-to-plasma membrane trafficking, underscoring its significance in cellular membrane dynamics. Furthermore, PI4KB emerges as a key player in inner ear development, suggesting diverse regulatory functions beyond its role in membrane trafficking. In the context of microbial infection, PI4KB assumes a critical role in Aichi virus RNA replication, being recruited by ACBD3 at the viral replication sites. This multifaceted involvement highlights PI4KB's versatile contributions to cellular processes and viral replication mechanisms.

Human

Sf9 insect cells

N-8*His;N-GST

Q9UBF8 (G2-M816)

5298

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.