LOX-1
LOX-1, the lectin-like oxidized LDL receptor-1 encoded by OLR1, is the principal scavenger receptor for oxidized LDL on vascular endothelium, and it is also found on macrophages, platelets, and smooth-muscle cells. A type II membrane protein with a short cytoplasmic tail, a helically twisted neck, and a C-type lectin-like domain, it is induced by oxLDL itself, shear stress, angiotensin II, and inflammatory cytokines. Ligand binding activates NF-κB and MAPK signaling, generating reactive oxygen species, adhesion molecules, and endothelial dysfunction that drive atherogenesis; a shed soluble form may serve as a cardiovascular biomarker. Recombinant LOX-1 is used in oxLDL-binding assays and atherosclerosis research.
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LOX-1 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
