2. Recombinant Proteins
  3. Receptor Proteins
  4. Pattern Recognition Receptors
  5. C-type Lectin Receptors
  6. C-Type Lectin Domain Containing 6A/Dectin-2

C-Type Lectin Domain Containing 6A/Dectin-2

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C-Type Lectin Domain Containing 6A/Dectin-2

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72967
    Dectin-2/CLEC6A Protein, Mouse (HEK293, His)

    C-type lectin domain family 6 member A; Dectin-2; Clec6a; Clec4n; Clecsf10

    		Mouse HEK293
    Dectin-2/CLEC6A protein has carbohydrate binding and pattern recognition receptor activities, and is involved in the positive regulation of I-kappaB kinase/NF-kappaB signaling, immune response regulation, and fungal response. It is predicted to reside in membranes, particularly on the outside of the plasma membrane, and it is expressed in a variety of tissues, including bone marrow, embryos, lungs, spleen, and thymus. Dectin-2/CLEC6A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Dectin-2/CLEC6A Protein, Mouse (HEK293, His) is 166 a.a., with molecular weight of ~23 kDa.
  • HY-P74201
    Dectin-2/CLEC6A Protein, Human (HEK293, Fc)

    C-type lectin domain family 6 member A; Dectin-2; Clec6a; Clec4n; Clecsf10

    		Human HEK293
    Dectin-2, also known as CLEC6A, functions as a calcium-dependent lectin and pattern recognition receptor (PRR) within the innate immune system, exhibiting specific recognition and binding to alpha-mannans on C. albicans hyphae. Upon binding of C. albicans alpha-mannans, this receptor complex initiates the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, thereby activating SYK, CARD9, and NF-kappa-B. This cascade of events drives the maturation of antigen-presenting cells and influences antigen-specific priming of T-cells, favoring the development of effector T-helper 1 and T-helper 17 cell subtypes. In addition to its role in antifungal defense, Dectin-2 recognizes allergens from house dust mites and fungi in a mannose-dependent manner, promoting cysteinyl leukotriene production. Moreover, it plays a role in altering adaptive immune responses by recognizing soluble elements from the eggs of Schistosoma mansoni. Associated with FCER1G, Dectin-2 forms a heterodimer with CLEC4D, establishing a pattern recognition receptor against fungal infections. The multifaceted functions of Dectin-2 underscore its importance in immune surveillance and response mechanisms. Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is the recombinant human-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is 168 a.a., with molecular weight of ~52 kDa.
Cat. No. Product Name Effect Purity