CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi)

CLEC12A/MICL (C-type lectin domain family 12 member A/myelosuppressive C-type lectin-like receptor) is a cell surface receptor that acts as a modulator of signaling cascades, specifically promoting target MAP kinases Protease. CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with C-Avi, N-His labeled tag.

CLEC12A/MICL (C-type lectin domain family 12 member A/Myeloid inhibitory C-type lectin-like receptor) is a cell surface receptor that functions as a regulator of signaling cascades, specifically facilitating the tyrosine phosphorylation of target MAP kinases. Through its interactions with PTPN6 and PTPN11, CLEC12A/MICL is implicated in intricate cellular signaling processes, suggesting its significance in modulating immune responses and potentially serving as a target for therapeutic interventions aimed at manipulating immune system function.

1. Immobilized Anti-CLEC12A Antibody,hFc Tag at 1ug/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human CLEC12A,His Tag with the EC₅₀ of 0.53ug/ml determined by ELISA.
2. Loaded Tepoditamab (HY-P99390) on AHC2 biosensor, can bind CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi) with an affinity constant of 1.185E-08 M as determined in BLI assay.

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  Loaded Tepoditamab (HY-P99390) on AHC2 biosensor, can bind CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi) with an affinity constant of 1.185E-08 M as determined in BLI assay.

Human

HEK293

C-Avi;N-His

Q5QGZ9-2 (H65-A265)

160364  [NCBI]

Extracellular Domain

Biotin

HVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRELYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFIKSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHCTYKKRMICEKMANPVQLGSTYFREA

40-60 kDa

≥ 95%, as determined by Bis-Tris PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 5% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.