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Tepoditamab

(Synonyms: MCLA 117)
Customer Review

Based on 1 Customer Validation

Tepoditamab (MCLA-117) is a full-length human IgG1 bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells. Tepoditamab induces upto 30-fold T-cell expansion. Tepoditamab results in moderate to strong cytokine (IFNγ, IL-6, IL-8, IL-10, and TNFα) and IFNγ release in human whole blood and PBMC, respectively. Tepoditamab can be used in acute myeloid leukaemia (AML) research.

For research use only. We do not sell to patients.

  • Purity: ≥99%
  • CAS No.: 2044679-53-8
  • Molecular Weight:144.787 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Tepoditamab Chemical Structure
    Tepoditamab Chemical Structure
CAS No.: 2044679-53-8
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Tepoditamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded Tepoditamab on AHC2 biosensor, can bind CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi, HY-P77633) with an affinity constant of 1.185E-08 M as determined in BLI assay.

  • 1/16

    Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Tepoditamab. The EC50 for this effect is 74.47 ng/mL.

  • 1/16

    Immobilized CLEC12A/MICL Protein, Human (HEK293, Fc, HY-P77631) can bind Tepoditamab. The EC50 for this effect is 67.71 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tepoditamab (HY-P99390). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Tepoditamab Chemical Structure
    1/16
  • Tepoditamab
  • Loaded Tepoditamab on AHC2 biosensor, can bind CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi, HY-P77633) with an affinity constant of 1.185E-08 M as determined in BLI assay.
  • Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Tepoditamab. The EC50 for this effect is 74.47 ng/mL.
  • Immobilized CLEC12A/MICL Protein, Human (HEK293, Fc, HY-P77631) can bind Tepoditamab. The EC50 for this effect is 67.71 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tepoditamab (HY-P99390). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.