CLL-1
CLL-1, also designated CLEC12A or MICL, is an inhibitory C-type lectin receptor carried on granulocytes, monocytes, dendritic cells, and, critically, on leukemia stem cells in most acute myeloid leukemia patients while being absent from normal hematopoietic stem cells. Its cytoplasmic ITIM recruits SHP-1/SHP-2 phosphatases to dampen myeloid activation, and its ligand remains unconfirmed. This stem-cell-restricted tumor expression has made CLL-1 a leading target for AML-directed CAR-T cells and bispecific antibodies, where sparing normal HSCs is essential. Recombinant CLL-1/CLEC12A protein is used to evaluate binding of CAR constructs and antibodies and to study inhibitory signaling in myeloid cells.
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CLL-1 Recombinant Proteins (8)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
