Langerin/CD207 Protein, Mouse (His)

Langerin, also known as CD207, is a calcium-dependent lectin with mannose-binding specificity. Notably, it induces the formation of Birbeck granules (BG) and acts as an effective regulator of membrane stacking and zipping. Langerin/CD207 Protein, Mouse (His) is the recombinant mouse-derived Langerin/CD207 protein, expressed by E. coli , with N-His labeled tag. The total length of Langerin/CD207 Protein, Mouse (His) is 269 a.a., with molecular weight of ~34.7 kDa.

Langerin, also known as CD207, is a calcium-dependent lectin with a specific affinity for mannose. This protein plays a crucial role in antigen uptake and processing. Langerin induces the formation of Birbeck granules (BGs) and acts as a potent regulator of membrane superimposition and zippering. It demonstrates binding capabilities not only to mannosylated glycans but also to sulfated glycans such as keratan sulfate (KS) and beta-glucans. As a homotrimer, Langerin facilitates the uptake of antigens and is involved in the routing and processing of antigens for presentation to T cells. The multifaceted functions of Langerin highlight its significance in immune response modulation and antigen presentation pathways.

Mouse

E. coli

N-His

Q8VBX4 (63Q-331E)

246278  [NCBI]

QAVFYPRLMGKILDVKSDAQMLKGRVDNISTLGSDLKTERGRVDDAEVQMQIVNTTLKRVRSQILSLETSMKIANDQLQILTMSWGEVDSLSAKIPELKRDLDKASALNTKVQGLQNSLENVNKLLKQQSDILEMVARGWKYFSGNFYYFSRTPKTWYSAEQFCISRKAHLTSVSSESEQKFLYKAADGIPHWIGLTKAGSEGDWYWVDQTSFNKEQSRRFWIPGEPNNAGNNEHCANIRVSALKCWNDGPCDNTFLFICKRPYVQTTE

Approximately 34.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.