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CD206/MMR Protein, Mouse (HEK293, His)

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Based on 1 Customer Validation

The CD206/MMR protein acts as a multifunctional mediator in macrophages, promoting glycoprotein internalization. It has a broad binding capacity, interacting with both sulfated and non-sulfated polysaccharide chains. CD206/MMR Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD206/MMR protein, expressed by HEK293 , with C-6*His labeled tag.

For research use only. We do not sell to patients.
  • Species: Mouse
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • Experimental Validation Results for CD206/MMR Protein, Mouse (HEK293, His)
  • Experimental Validation Results for CD206/MMR Protein, Mouse (HEK293, His)
  • CD206/MMR Protein, Mouse (HEK293, His) Product Image
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

The CD206/MMR protein acts as a multifunctional mediator in macrophages, promoting glycoprotein internalization. It has a broad binding capacity, interacting with both sulfated and non-sulfated polysaccharide chains. CD206/MMR Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD206/MMR protein, expressed by HEK293 , with C-6*His labeled tag.

Background

CD206/MMR Protein plays a pivotal role in cellular processes, acting as a versatile mediator of endocytosis in macrophages, specifically facilitating the internalization of glycoproteins. The protein exhibits a broad binding capacity, interacting with both sulfated and non-sulfated polysaccharide chains. In the context of microbial infection, CD206/MMR further assumes a critical role as a phagocytic receptor, contributing to the recognition and engulfment of bacteria, fungi, and other pathogens. This multifaceted functionality underscores CD206/MMR's significance in orchestrating the cellular response to glycoproteins and microbial challenges, showcasing its role as a key player in innate immunity and cellular homeostasis.

Verified Bioactivity

Measured by its binding ability in a functional ELISA. When Mannan is coated at 0.2 μg/mL (100 μL/well) can bind Recombinan Mouse CD206. The ED50 for this effect is 0.485μg/mL.

MCE Validation Data

  • Purity - SDS-PAGE

    Purity - SDS-PAGE

    ≥ 95%, as determined by reducing SDS-PAGE.

  • Bioactivity - ELISA

    Bioactivity - ELISA

    Measured by its binding ability in a functional ELISA. When Mannan is coated at 0.2 μg/mL (100 μL/well) can bind Recombinan Mouse CD206. The ED50 for this effect is 0.485 μg/mL.

Technical Parameters

  • Species Mouse
  • Source HEK293
  • Tag C-6*His
  • Accession

    Q2HZ94 (L19-A1388)

  • Gene ID
    17533
  • Molecular Construction
    • N-term
    • CD206 (L19-A1388)
      Accession # Q2HZ94
    • 6*His
    • C-term
  • Protein Length

    Partial

  • Synonyms

    MRC1; Macrophage Mannose Receptor 1; Prev. MRC1L1; MMR; CLEC13DL; HMR; CLEC13D; C-Type Lectin Domain Family 13 Member D-Like; BA541I19.1; Macrophage Mannose Receptor; CD206; Mannose Receptor, C Type 1; Macrophage Mannose Receptor 1-Like Protein 1; Alterna

  • AA Sequence

    LLDARQFLIYNEDHKRCVDALSAISVQTATCNPEAESQKFRWVSDSQIMSVAFKLCLGVPSKTDWASVTLYACDSKSEYQKWECKNDTLFGIKGTELYFNYGNRQEKNIKLYKGSGLWSRWKVYGTTDDLCSRGYEAMYSLLGNANGAVCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDKDKLFGFCPLHFEGSERLWNKDPLTGILYQINSKSALTWHQARASCKQQNADLLSVTEIHEQMYLTGLTSSLSSGLWIGLNSLSVRSGWQWAGGSPFRYLNWLPGSPSSEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNNTLNPFIIPSASDVPTGCPNQWWPYAGHCYRIHREEKKIQKYALQACRKEGGDLASIHSIEEFDFIFSQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLPGEPSHENNRQEDCVVMKGKDGYWADRACEQPLGYICKMVSQSHAVVPEGADKGCRKGWKRHGFYCYLIGSTLSTFTDANHTCTNEKAYLTTVEDRYEQAFLTSLVGLRPEKYFWTGLSDVQNKGTFRWTVDEQVQFTHWNADMPGRKAGCVAMKTGVAGGLWDVLSCEEKAKFVCKHWAEGVTRPPEPTTTPEPKCPENWGTTSKTSMCFKLYAKGKHEKKTWFESRDFCKAIGGELASIKSKDEQQVIWRLITSSGSYHELFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPGMSWNDINCEHLNNWICQIQKGKTLLPEPTPAPQDNPPVTADGWVIYKDYQYYFSKEKETMDNARAFCKKNFGDLATIKSESEKKFLWKYINKNGGQSPYFIGMLISMDKKFIWMDGSKVDFVAWATGEPNFANDDENCVTMYTNSGFWNDINCGYPNNFICQRHNSSINATAMPTTPTTPGGCKEGWHLYKNKCFKIFGFANEEKKSWQDARQACKGLKGNLVSIENAQEQAFVTYHMRDSTFNAWTGLNDINAEHMFLWTAGQGVHYTNWGKGYPGGRRSSLSYEDADCVVVIGGNSREAGTWMDDTCDSKQGYICQTQTDPSLPVSPTTTPKDGFVTYGKSSYSLMKLKLPWHEAETYCKDHTSLLASILDPYSNAFAWMKMHPFNVPIWIALNSNLTNNEYTWTDRWRVRYTNWGADEPKLKSACVYMDVDGYWRTSYCNESFYFLCKKSDEIPATEPPQLPGKCPESEQTAWIPFYGHCYYFESSFTRSWGQASLECLRMGASLVSIETAAESSFLSYRVEPLKSKTNFWIGMFRNVEGKWLWLNDNPVSFVNWKTGDPSGERNDCVVLASSSGLWNNIHCSSYKGFICKMPKIIDPVTTHSSITTKADQRKMDPQPKGSSKA

  • Molecular Weight

    Approximately 141-170 kDa, based on SDS-PAGE under reducing conditions.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<0.1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in PBS.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     ≥ 95%, as determined by reducing SDS-PAGE.

  • 1/16

    MedChemExpress Validation
     Measured by its binding ability in a functional ELISA. When Mannan is coated at 0.2 μg/mL (100 μL/well) can bind Recombinan Mouse CD206. The ED50 for this effect is 0.485 μg/mL.

  • CD206/MMR Protein, Mouse (HEK293, His) Product Image
    1/16
  • Experimental Validation Results for CD206/MMR Protein, Mouse (HEK293, His)
  • Experimental Validation Results for CD206/MMR Protein, Mouse (HEK293, His)
  • CD206/MMR Protein, Mouse (HEK293, His) Product Image