Collectin-12
Collectin-12, also known as collectin placenta 1 or COLEC12, is a membrane-anchored collectin expressed chiefly by vascular endothelium, placenta, and macrophages. Unlike its soluble relative collectin liver 1, it retains a transmembrane region and presents trimeric carbohydrate-recognition domains on the cell surface, where it binds bacterial sugars including lipopolysaccharide mannosyl arrays. Although it has not been shown to activate complement through MASP association like the secreted collectins, it promotes opsonophagocytosis and modulates inflammatory responses of endothelial and myeloid cells, and variants have been linked to preeclampsia susceptibility. Recombinant collectin-12 supports endothelial innate-immunity and infection research.
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Collectin-12 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
