CL-P1/COLEC12 Protein, Rat (sf9, His)

CL-P1/COLEC12 is a multifunctional scavenger receptor that effectively defends against microorganisms and promotes their binding and phagocytosis, covering Gram-positive and Gram-negative bacteria and yeast. In addition, it mediates the recognition, internalization, and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. CL-P1/COLEC12 Protein, Rat (sf9, His) is the recombinant rat-derived CL-P1/COLEC12 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of CL-P1/COLEC12 Protein, Rat (sf9, His) is 642 a.a., with molecular weight of ~90 KDa.

CL-P1/COLEC12, a multifaceted scavenger receptor, plays a crucial role in host defense by promoting the binding and phagocytosis of various microbes, encompassing Gram-positive and Gram-negative bacteria as well as yeast. Additionally, it functions as a key mediator in the recognition, internalization, and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. The receptor exhibits versatile carbohydrate-binding capabilities, interacting with Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T, and Tn antigens in a calcium-dependent manner. Specifically, it internalizes GalNAc in nurse-like cells and binds to sialyl Lewis X, a trisaccharide, and asialo-orosomucoid (ASOR). Notably, the extracellular domain of CL-P1/COLEC12 forms a stable trimer and engages in interactions with fibrillar amyloid-beta peptide, suggesting its potential involvement in processes related to amyloid-beta pathology.

Rat

Sf9 insect cells

N-His

Q4V885 (A101-L742)

361289  [NCBI]

Approximately 90 kDa.

Greater than 90% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 300 mM NaCl, 10% glycerol, pH 7.5.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.