MDL-1/CLEC5A
MDL-1 (CLEC5A), also known as TREM-like transcript 1, is an activating C-type lectin receptor expressed on macrophages, dendritic cells, neutrophils, and osteoclasts. Unusual in this family, it lacks intrinsic signaling motifs and instead associates with the adaptor DAP12, coupling ligand binding to Syk-dependent activation. MDL-1 came to prominence when dengue virus was shown to engage it on myeloid cells, triggering cytokine release that drives hemorrhagic fever in mouse models; blocking antibodies proved protective. It also participates in osteoclast differentiation and in responses to other flaviviruses. Recombinant MDL-1/CLEC5A is used to study viral immunopathology, DAP12-coupled receptor signaling, and bone-immune interactions.
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MDL-1/CLEC5A Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
