BDCA-2
BDCA-2 (CLEC4C) is a defining surface marker of human plasmacytoid dendritic cells and a therapeutic target in interferon-driven autoimmune disease. This type II transmembrane C-type lectin lacks a signaling tail of its own and couples to the Fc receptor gamma-chain; importantly, its engagement transmits an inhibitory signal that blocks TLR-induced type I interferon and chemokine production. It also functions as an endocytic receptor, internalizing bound antigens for presentation. Because plasmacytoid dendritic cells are major interferon-alpha producers in systemic lupus erythematosus, BDCA-2-directed antibodies are being developed to deplete or silence these cells. Recombinant BDCA-2 supports pDC biology, lupus research, and biologic-drug screening.
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BDCA-2 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
