IL1RL2 - interleukin 1 receptor like 2 Gene

Also Known as IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8808

About IL1RL2

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,186,973-102,243,086 (from NCBI)

This gene has 4 transcripts (splice variants), 101 orthologues and 10 paralogues. Biased expression in skin (RPKM 3.4), esophagus (RPKM 1.6) and 11 other tissues.

Summary

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four Other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

IL1RL2 Products (6)

mRNA	Protein	Name
NM_001351446.2	NP_001338375.1	interleukin-1 receptor-like 2 isoform a precursor
NM_001351447.1	NP_001338376.1	interleukin-1 receptor-like 2 isoform b
NM_001351448.1	NP_001338377.1	interleukin-1 receptor-like 2 isoform c
NM_001351449.2	NP_001338378.1	interleukin-1 receptor-like 2 isoform d
NM_001351450.2	NP_001338379.1	interleukin-1 receptor-like 2 isoform d
NM_003854.4	NP_003845.2	interleukin-1 receptor-like 2 isoform a precursor

IL1RL2 Protein Structure

Ig_2

TIR

0
100
200
300
400
500
575 a.a.

Protein Preferred Names	Protein Names
interleukin-1 receptor-like 2	IL-1 receptor-related protein 2

Recombinant IL1RL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70603	IL-1RL2 Protein, Human (HEK293, His)	Q9HB29 (D20-Y337)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70625	IL-1RL2 Protein, Human (HEK293, Fc)	Q9HB29 (D20-Y337)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78145	IL-1RL2 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9HB29 (D20-R335)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78462	IL-1RL2 Protein, Human (HEK293, His-Avi)	Q9HB29 (D20-R335)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78547	IL-1RL2 Protein, Human (C154S, C262S, HEK293, His)	Q9HB29 (D20-Y337, C154S, C262S)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Familial Cold Autoinflammatory Syndrome 2	FCAS2 Nlrp12-Associated Hereditary Periodic Fever Syndrome Familial Cold Autoinflammatory Syndrome Type 2 Familial Cold-Induced Autoinflammatory Syndrome Type 2 Naps12 Familial Cold Autoinflammatory Syndrome 2, Susceptibility To Autoinflammatory Syndrome, Cold, Familial, Type 2
Pustulosis Of Palm And Sole	Psoriasis Acropustulosis Palmoplantar Pustulosis Pustular Psoriasis Of The Palms And/Or Soles Pustulosis Of Palms And Soles Acrodermatitis Continua Of Hallopeau Generalized Pustular Psoriasis
Impetigo Herpetiformis
Psoriasis 14, Pustular	Generalized Pustular Psoriasis Gpp Ditra Acrodermatitis Continua Of Hallopeau Palmoplantar Pustulosis PSORS14 Interleukin 36 Receptor Antagonist Deficiency Psorp Pustular Psoriasis 14 Deficiency Of Il-36r Antagonist Acute Generalised Pustular Psoriasis Deficiency Of The Interleukin-36 Receptor Antagonist Generalized Pustular Psoriasis Of Von Zumbusch Von Zumbusch Psoriasis Deficiency Of Il-36ra Psoriasis, Pustular, Generalized Psoriasis, Pustular, Type 14 Pustulosis Of Palms And Soles Acute Generalized Pustular Psoriasis Palmoplantar Pustular Psoriasis Pustulosis Palmaris Et Plantaris Ppp - [Palmoplantar Pustulosis] Pustular Psoriasis Of The Palms And Soles Pustular Bacterid
Pityriasis Rubra Pilaris	PRP Devergie'S Disease Prp - [Pityriasis Rubra Pilaris]
Geographic Tongue	Benign Migratory Glossitis Glossitis Areata Exfoliativa Glossitis, Benign Migratory Pityriasis Linguae Ectopic Geographic Tongue Erythema Migrans Erythema Chronicum Migrans Benign Migrating Glossitis Geographical Tongue Lingua Geographica Erythema Migrans Of Tongue Wandering Rash Of Tongue
Atrophic Glossitis	Atrophy Of Tongue Papillae Glossitis, Hunter'S Hunter'S Glossitis Smooth Atrophic Tongue Hunter Glossitis Central Papillary Atrophy Of The Tongue
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne	Papa Syndrome Fra Familial Recurrent Arthritis Pyogenic Arthritis, Pyoderma Gangrenosum And Acne PAPAS Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne
Neutrophilic Dermatosis, Acute Febrile	Sweet Syndrome Acute Febrile Neutrophilic Dermatosis Ss AFND Pyrin-Associated Autoinflammatory Disease PAAND Gomm-Button Disease Sweet'S Syndrome Gomm Button Disease Sweets Syndrome Acromelic Frontonasal Dysostosis Sweet Disease
Periodic Fever, Familial, Autosomal Dominant	Familial Hibernian Fever Tumor Necrosis Factor Receptor-Associated Periodic Syndrome Traps FPF Tnf Receptor-Associated Periodic Fever Syndrome Hibernian Fever, Familial Fhf Tnf Receptor-Associated Periodic Syndrome Autosomal Dominant Familial Periodic Fever Periodic Fever, Familial Tnf Receptor 1-Associated Periodic Syndrome Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome Familial Periodic Fever Traps Syndrome Tnf Receptor Associated Periodic Syndrome Caledonian Fever Fever, Periodic, Familial Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
Periostitis
Mevalonic Aciduria	Mevalonate Kinase Deficiency Mevalonicaciduria Hyperimmunoglobulin D With Periodic Fever MEVA Complete Mevalonate Kinase Deficiency Mva Hyperimmunoglobulinemia D Hyper Igd Syndrome Periodic Fever, Dutch Type Mkd Aciduria, Mevalonic Deficiency Of Mevalonate Kinase
Acrodermatitis
Psoriasis 11	PSORS11 Psoriasis Susceptibility 11 Psoriasis Psoriasis Vulgaris Psoriasis 11, Susceptibility To Pv
Impetigo
Autoimmune Disease Of Skin And Connective Tissue
Good Syndrome	Immunodeficiency With Thymoma Thymoma-Immunodeficiency Syndrome Thymoma With Hypogammaglobulinemia Thymoma Immunodeficiency
Diamond-Blackfan Anemia 1	Aase Syndrome DBA1 Erythrogenesis Imperfecta Aase-Smith Syndrome Ii Dba Blackfan-Diamond Syndrome Bds Anemia, Congenital Hypoplastic, Of Blackfan And Diamond Anemia, Congenital Erythroid Hypoplastic Red Cell Aplasia, Pure, Hereditary Aregenerative Anemia, Chronic Congenital Rps19-Related Diamond-Blackfan Anemia Chronic Congenital Aregenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Pure Hereditary Red Cell Aplasia Anemia, Diamond-Blackfan, Type 1 Anemia, Diamond-Blackfan Aase Smith Syndrome 2 Familial Hypoplastic Anaemia With Malformations Constitutional Pure Red Cell Aplasia
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991281	REGN6490	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06726	IL1RL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20168	Il1rl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26672	Il1rl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991019	Recibokibart	Inhibitor	99%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IL1RL2	VGNC	VGNC:30135
Canis familiaris	IL1RL2	VGNC	VGNC:108207
Macaca mulatta	IL1RL2	VGNC	VGNC:73722
Felis catus	IL1RL2	VGNC	VGNC:67769
Mus musculus	IL1RL2	MGD	MGI:1913107
Rattus norvegicus	IL1RL2	RGD	RGD:621782
Others	IL1RL2	NCBI