IL1RL2 - interleukin 1 receptor like 2 Gene

Homo sapiens

Also known as IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2

Gene ID: 8808 | Gene type: protein coding

About IL1RL2

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,186,973-102,243,086 (from NCBI)

This gene has 4 transcripts (splice variants), 101 orthologues and 10 paralogues. Biased expression in skin (RPKM 3.4), esophagus (RPKM 1.6) and 11 other tissues.

Summary

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

IL1RL2 Products(6)

mRNA	Protein	Name
NM_001351446.2	NP_001338375.1	interleukin-1 receptor-like 2 isoform a precursor
NM_001351447.1	NP_001338376.1	interleukin-1 receptor-like 2 isoform b
NM_001351448.1	NP_001338377.1	interleukin-1 receptor-like 2 isoform c
NM_001351449.2	NP_001338378.1	interleukin-1 receptor-like 2 isoform d
NM_001351450.2	NP_001338379.1	interleukin-1 receptor-like 2 isoform d
NM_003854.4	NP_003845.2	interleukin-1 receptor-like 2 isoform a precursor

IL1RL2 Protein Structure

Ig_2

TIR

0
100
200
300
400
500
575 a.a.

Protein Preferred Names

Protein Names

interleukin-1 receptor-like 2

IL-1 receptor-related protein 2

Recombinant IL1RL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70603	IL-1RL2 Protein, Human (HEK293, His)	Q9HB29 (D20-Y337)	≥95%
HY-P70625	IL-1RL2 Protein, Human (HEK293, Fc)	Q9HB29 (D20-Y337)	≥95%
HY-P71970	IL-1RL2 Protein, Human (HEK 293, hFc)	Q9HB29 (D20-Y337)	≥95%
HY-P78145	IL-1RL2 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9HB29 (D20-R335)	≥95%
HY-P78462	IL-1RL2 Protein, Human (HEK293, His-Avi)	Q9HB29 (D20-R335)	≥95%
HY-P78547	IL-1RL2 Protein, Human (C154S, C262S, HEK293, His)	Q9HB29 (D20-Y337, C154S,C262S)	≥95%

Related Diseases

Diseases

Alias

Familial Cold Autoinflammatory Syndrome 2

FCAS2	Nlrp12-Associated Hereditary Periodic Fever Syndrome
Familial Cold Autoinflammatory Syndrome Type 2	Familial Cold-Induced Autoinflammatory Syndrome Type 2
Naps12	Familial Cold Autoinflammatory Syndrome 2, Susceptibility To
Autoinflammatory Syndrome, Cold, Familial, Type 2

Pustulosis Of Palm And Sole

Psoriasis	Acropustulosis
Palmoplantar Pustulosis	Pustular Psoriasis Of The Palms And/Or Soles
Pustulosis Of Palms And Soles	Acrodermatitis Continua Of Hallopeau
Generalized Pustular Psoriasis

Impetigo Herpetiformis

Psoriasis 14, Pustular

Generalized Pustular Psoriasis	Gpp
Ditra	Acrodermatitis Continua Of Hallopeau
Palmoplantar Pustulosis	PSORS14
Interleukin 36 Receptor Antagonist Deficiency	Psorp
Pustular Psoriasis 14	Deficiency Of Il-36r Antagonist
Acute Generalised Pustular Psoriasis	Deficiency Of The Interleukin-36 Receptor Antagonist
Generalized Pustular Psoriasis Of Von Zumbusch	Von Zumbusch Psoriasis
Deficiency Of Il-36ra	Psoriasis, Pustular, Generalized
Psoriasis, Pustular, Type 14	Pustulosis Of Palms And Soles
Acute Generalized Pustular Psoriasis	Palmoplantar Pustular Psoriasis
Pustulosis Palmaris Et Plantaris	Ppp - [Palmoplantar Pustulosis]
Pustular Psoriasis Of The Palms And Soles	Pustular Bacterid

Pityriasis Rubra Pilaris

PRP	Devergie'S Disease
Prp - [Pityriasis Rubra Pilaris]

Geographic Tongue

Benign Migratory Glossitis	Glossitis Areata Exfoliativa
Glossitis, Benign Migratory	Pityriasis Linguae
Ectopic Geographic Tongue	Erythema Migrans
Erythema Chronicum Migrans	Benign Migrating Glossitis
Geographical Tongue	Lingua Geographica
Erythema Migrans Of Tongue	Wandering Rash Of Tongue

Atrophic Glossitis

Atrophy Of Tongue Papillae	Glossitis, Hunter'S
Hunter'S Glossitis	Smooth Atrophic Tongue
Hunter Glossitis	Central Papillary Atrophy Of The Tongue

Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne

Papa Syndrome	Fra
Familial Recurrent Arthritis	Pyogenic Arthritis, Pyoderma Gangrenosum And Acne
PAPAS	Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne	Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne

Neutrophilic Dermatosis, Acute Febrile

Sweet Syndrome	Acute Febrile Neutrophilic Dermatosis
Ss	AFND
Pyrin-Associated Autoinflammatory Disease	PAAND
Gomm-Button Disease	Sweet'S Syndrome
Gomm Button Disease	Sweets Syndrome
Acromelic Frontonasal Dysostosis	Sweet Disease

Periodic Fever, Familial, Autosomal Dominant

Familial Hibernian Fever	Tumor Necrosis Factor Receptor-Associated Periodic Syndrome
Traps	FPF
Tnf Receptor-Associated Periodic Fever Syndrome	Hibernian Fever, Familial
Fhf	Tnf Receptor-Associated Periodic Syndrome
Autosomal Dominant Familial Periodic Fever	Periodic Fever, Familial
Tnf Receptor 1-Associated Periodic Syndrome	Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Familial Periodic Fever	Traps Syndrome
Tnf Receptor Associated Periodic Syndrome	Caledonian Fever
Fever, Periodic, Familial	Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome

Periostitis

Mevalonic Aciduria

Mevalonate Kinase Deficiency	Mevalonicaciduria
Hyperimmunoglobulin D With Periodic Fever	MEVA
Complete Mevalonate Kinase Deficiency	Mva
Hyperimmunoglobulinemia D	Hyper Igd Syndrome
Periodic Fever, Dutch Type	Mkd
Aciduria, Mevalonic	Deficiency Of Mevalonate Kinase

Acrodermatitis

Psoriasis 11

PSORS11	Psoriasis Susceptibility 11
Psoriasis	Psoriasis Vulgaris
Psoriasis 11, Susceptibility To	Pv

Impetigo

Autoimmune Disease Of Skin And Connective Tissue

Good Syndrome

Immunodeficiency With Thymoma	Thymoma-Immunodeficiency Syndrome
Thymoma With Hypogammaglobulinemia	Thymoma Immunodeficiency

Diamond-Blackfan Anemia 1

Aase Syndrome	DBA1
Erythrogenesis Imperfecta	Aase-Smith Syndrome Ii
Dba	Blackfan-Diamond Syndrome
Bds	Anemia, Congenital Hypoplastic, Of Blackfan And Diamond
Anemia, Congenital Erythroid Hypoplastic	Red Cell Aplasia, Pure, Hereditary
Aregenerative Anemia, Chronic Congenital	Rps19-Related Diamond-Blackfan Anemia
Chronic Congenital Aregenerative Anemia	Congenital Erythroid Hypoplastic Anemia
Congenital Hypoplastic Anemia Of Blackfan And Diamond	Pure Hereditary Red Cell Aplasia
Anemia, Diamond-Blackfan, Type 1	Anemia, Diamond-Blackfan
Aase Smith Syndrome 2	Familial Hypoplastic Anaemia With Malformations
Constitutional Pure Red Cell Aplasia

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06726	IL1RL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IL1RL2	VGNC	VGNC:30135
Canis familiaris	IL1RL2	VGNC	VGNC:108207
Macaca mulatta	IL1RL2	VGNC	VGNC:73722
Felis catus	IL1RL2	VGNC	VGNC:67769
Mus musculus	IL1RL2	MGD	MGI:1913107
Rattus norvegicus	IL1RL2	RGD	RGD:621782
Macaca fascicularis	IL1RL2	NCBI
Others	IL1RL2	NCBI

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