IL-1RL2 Protein, Human (C154S, C262S, HEK293, His)

IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (C154S, C262S, HEK293, His) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293 , with C-His labeled tag and C154S, C262S mutation.

IL-1RL2, a receptor for interleukin-36 (IL36A, IL36B, and IL36G), engages in complex signaling events upon binding to interleukin-36. Through association with the coreceptor IL1RAP, the interleukin-36 receptor complex is formed, orchestrating interleukin-36-dependent activation of NF-kappa-B, MAPK, and other pathways. This signaling system, akin to the IL-1 system, is implicated in local inflammatory responses within epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway.

Human

HEK293

C-6*His

Q9HB29 (D20-Y337, C154S, C262S)

8808  [NCBI]

Partial

DGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSSVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRSWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAY

Approximately 56-67 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.