IL-27R alpha/TCCR Protein, Human (HEK293, His)

IL-27R alpha/TCCR Protein, acting as a receptor for IL27, relies on IL6ST/GP130 for signal transduction, activating STAT3 and STAT1. It is also part of a complex with IL6ST/GP130 and CNTFR, functioning as a receptor for the neuroprotective peptide humanin. IL-27R alpha/TCCR is implicated in regulating Th1-type immune responses and participating in innate defense mechanisms. This receptor is a key component of a complex with IL6ST/GP130, IL27RA/WSX1, and CNTFR, interacting with the neuroprotective peptide humanin. IL-27R alpha/TCCR Protein, Human (HEK293, His) is the recombinant human-derived IL-27R alpha/TCCR protein, expressed by HEK293, with C-His labeled tag. The total length of IL-27R alpha/TCCR Protein, Human (HEK293, His) is 483 a.a., with molecular weight of 75-105 kDa.

IL-27R alpha/TCCR, a receptor for IL27, relies on IL6ST/GP130 to facilitate signal transduction in response to IL27, operating through STAT3 and STAT1 pathways. This receptor is also implicated in the recognition of the neuroprotective peptide humanin, forming a complex with IL6ST/GP130 and CNTFR. Beyond its involvement in the regulation of Th1-type immune responses, IL-27R alpha/TCCR is associated with innate defense mechanisms. It forms part of a receptor complex comprising IL6ST/GP130, IL27RA/WSX1, and CNTFR, and this complex interacts with the neuroprotective peptide humanin.

Human

HEK293

C-His

Q6UWB1 (G34-K516)

9466  [NCBI]

75-105 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.22μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.