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Cat. No.: HY-124183

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SX-576

SX-576 is a CXCR1 and CXCR2 antagonist with IC₅₀ values of 31 nM and 21 nM, respectively. SX-576 inhibits neutrophil infiltration in a rat model of pulmonary inflammation. SX-576 can be used in studies related to pulmonary inflammation.

For research use only. We do not sell to patients.

CAS No.: 1240494-14-7
Formula: C₂₀H₁₅BF₄N₂O₄S
Molecular Weight:466.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SX-576 Chemical Structure

CAS No.: 1240494-14-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

All CXCR Isoforms :

In Vitro

SX-576 inhibits GROα-mediated intracellular calcium release in isolated human polymorphonuclear leukocytes (PMNs) with an IC₅₀ of 22 ± 3 nM^[1].
SX-576 acts as a full antagonist in CXCR2-expressing cells in the PathHunter β-arrestin assay with an IC₅₀ of 130 ± 6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SX-576 (1 mg/kg; i.v.; three doses) potently inhibits ozone-induced pulmonary inflammation in rats, reducing neutrophil influx to near undetectable levels, lowering macrophage counts, and decreasing lung leakage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats^[1]
Dosage:

1 mg/kg
Administration:

i.v.; three doses (at t=0, t=5, t=9 hours)
Result:

Significantly decreased neutrophil influx to the lungs to near undetectable levels.
Significantly reduced macrophage influx.
Significantly reduced ozone-induced lung leakage, as measured by reduced BALF protein levels.

Chemical Information

CAS No. 1240494-14-7
Molecular Weight 466.21
Formula C₂₀H₁₅BF₄N₂O₄S
SMILES

O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC3=CC(OC(F)(F)F)=CC=C3B(O)O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Maeda DY, et al. Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model. Bioorg Med Chem Lett. 2015 Jun 1;25(11):2280-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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SX-576

All CXCR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SX-576 Related Classifications

HY-124183 Related Classifications