2801625-42-1
Chemical Structure
MRS4738
- CAS No.: 2801625-42-1
- Formula:C30H24F3NO2
- Molecular Weight:487.51
IUPAC Name: methyl 4-amino-5-iodopicolinate
InChIKey: PXJXLYRJAGOTQU-DFZDUAMZSA-N
SMILES: OC(C1=CC2=CC(C3=CC=C(C=C3)C(F)(F)F)=CC=C2C(C4=CC=C([C@@H]5[C@@H]6C[C@@H](NC6)C5)C=C4)=C1)=O
Biological Activity: MRS4738 is a human P2Y14-targeted inhibitor with an IC50 of 3.11 nM. MRS4738 suppresses inflammatory responses of pulmonary neutrophils and lymphocytes, reduces airway eosinophil accumulation, and alleviates mechanical hyperalgesia. MRS4738 can be applied to the research on the mechanisms of diseases associated with pulmonary inflammation, neuropathic pain and asthma[1][2].
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MRS4738 | MRS4738 is a human P2Y14-targeted inhibitor with an IC50 of 3.11 nM. MRS4738 suppresses inflammatory responses of pulmonary neutrophils and lymphocytes, reduces airway eosinophil accumulation, and alleviates mechanical hyperalgesia. MRS4738 can be applied to the research on the mechanisms of diseases associated with pulmonary inflammation, neuropathic pain and asthma. | |||||||||||||||||||||
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- [1]. Whitehead GS, et al. Effects of Purinergic Receptor Deletion or Pharmacologic Modulation on Pulmonary Inflammation in Mice. ACS pharmacology & translational science. 2022 Oct 14;5(10):973-984. [Content Brief]
- [2]. Wen Z, et al. Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2YR Antagonist. Journal of medicinal chemistry. 2022 Feb 24;65(4):3434-3459. [Content Brief]
Keywords
