ZBP1 PROTAC-1
ZBP1 PROTAC-1 is a PROTAC degrader targeting ZBP1, with a DC50 of 81.52 nM. ZBP1 PROTAC-1 uses a DNA aptamer to specifically bind ZBP1, recruits the VHL E3 ubiquitin ligase, and induces ZBP1 degradation via the ubiquitin-proteasome pathway. ZBP1 PROTAC-1 can partially restore the viability of H1N1-infected cells. ZBP1 PROTAC-1 can be used in studies related to viral pneumonia and influenza A H1N1 virus infection.
(Pink: Target protein ligand; Blue: VHL ligand (HY-125845); Black: linker).
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
ZBP1 81.52 nM (DC50) |
VHL |
In Vitro
ZBP1 PROTAC-1 (2a+aptamer) (100 nM) restores cell viability from 34.9% to 65.2% in H1N1-infected A549 cells[1].
ZBP1 PROTAC-1 (12.5-200 nM; 0-48 h) induces concentration-dependent degradation of ZBP1 in cells with CBL0137 (HY-18935)-induced ZBP1 overexpression, with a DC50 of 81.52 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cells pre-treated with CBL0137 to upregulate ZBP1
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Concentration:12.5, 25, 50, 100 and 200 nM
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Incubation Time:0, 6, 12, 24, 36 and 48 h
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Result:In CBL0137-induced ZBP1-overexpressing cells, ZBP1 was degraded in a concentration-dependent manner, with a DC50 of 81.52 nM.
Chemical Information
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SMILES
O=C(CCCCC(N[3'-AAGTGCCATCGTGCGTATCCCTCGCGTCTGCTTGCTC GTCCCAACCCACCACCGCCCGATACGCACCTCACGACHTT-5'])=O)N1C2=C(C3=C(C4=C(C1)C=CC=C4)N(CCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)O)=O)=O)N=N3)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZBP1 PROTAC-1 Related Classifications
HY-185102 Related Classifications
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