Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro

Pafuramidine is a novel orally active antimalarial. To identify a combination partner, we measured the in vitro antimalarial activities of the active metabolite, DB75, with amodiaquine, artemisinin, atovaquone, azithromycin, chloroquine, clindamycin, mefloquine, piperaquine, pyronaridine, tafenoquine, and Tetracycline. None of the drugs tested demonstrated antagonistic or synergistic activity in combination with pafuramidine.