1. Others Anti-infection Metabolic Enzyme/Protease
  2. Isotope-Labeled Compounds Parasite Fungal Phosphatase Bacterial Antibiotic
  3. Pentamidine-d4 dihydrochloride

Pentamidine-d4 dihydrochloride  (Synonyms: MP-601205-d4(dihydrochloride))

Cat. No.: HY-B0537AS Purity: ≥98.0%
COA Handling Instructions

Pentamidine-d4 (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

For research use only. We do not sell to patients.

Pentamidine-d<sub>4</sub> dihydrochloride Chemical Structure

Pentamidine-d4 dihydrochloride Chemical Structure

CAS No. : 1276197-32-0

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Based on 1 publication(s) in Google Scholar

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Description

Pentamidine-d4 (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

IC50 & Target

Trypanosoma

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

417.37

Formula

C19H22D4Cl2N4O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(C1=CC=C(C=C1)OC([2H])([2H])CCCC([2H])([2H])OC2=CC=C(C=C2)C(N)=N)N.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥98.0%

References
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Product Name:
Pentamidine-d4 dihydrochloride
Cat. No.:
HY-B0537AS
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