1. Anti-infection
    Metabolic Enzyme/Protease
  2. Parasite
    Fungal
    Phosphatase
    Bacterial
    Antibiotic
  3. Pentamidine dihydrochloride

Pentamidine dihydrochloride (Synonyms: MP-601205 dihydrochloride)

Cat. No.: HY-B0537A
Handling Instructions

Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.

For research use only. We do not sell to patients.

Pentamidine dihydrochloride Chemical Structure

Pentamidine dihydrochloride Chemical Structure

CAS No. : 50357-45-4

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Description

Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

IC50 & Target

IC50: 2.5 μM (Leishmania infantum)[2]
Protein tyrosine phosphatases (PTPases)[1]
Phosphatase of regenerating liver (PRL)[1]

In Vitro

Pentamidine (0-10 µg/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, and A549 cells) treatment inhibits the growth of cancer cells in a concentration-dependent manner[1].
The cytotoxic properties of Pentamidine isethionate towards the promastigotes of the protozoan parasite Leishmania infantum is determined. The leishmanicidal activity of Pentamidine isethionate is 60 times higher after 72 h of incubation than that of Cisplatin. Pentamidine isethionate induces a higher amount of programmed cell death (PCD) than Cisplatin, which is associated with inhibition of DNA synthesis and cell-cycle arrest in the G2/M phase. Binding of Pentamidine isethionate to calf-thymus DNA (CT-DNA) induces conformational changes in the DNA double helix, consistent with a B-->A transition. The interaction of Pentamidine isethionate with ubiquitin leads to a 6% increase in the beta-sheet content of the protein[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: WM9, DU145, C4-2, Hey, WM480, and A549 cells
Concentration: 0-10 µg/mL
Incubation Time: 6 days
Result: The growth of all six of the cell lines in culture was inhibited in a concentration-dependent manner with complete growth inhibition of the cell lines occurring at 10 µg/mL.
In Vivo

Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (6 weeks old) injected with WM9 cells[1]
Dosage: 0.25 mg/mouse
Administration: Intramuscular injection; every 2 days; for 4 weeks
Result: Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.
Clinical Trial
Molecular Weight

413.34

Formula

C₁₉H₂₆Cl₂N₄O₂

CAS No.
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Storage

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References
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Pentamidine dihydrochloride
Cat. No.:
HY-B0537A
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