1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
    Anti-infection
  2. PKA
    Parasite
  3. Jaspamycin

Jaspamycin (Synonyms: 7-CN-7-C-Ino)

Cat. No.: HY-111759 Purity: 98.73%
Handling Instructions

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.

For research use only. We do not sell to patients.

Jaspamycin Chemical Structure

Jaspamycin Chemical Structure

CAS No. : 22242-96-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].

IC50 & Target[1]

Trypanosoma brucei PKAR(199-499)

6.5 nM (EC50)

Trypanosoma brucei PKA holoenzyme

8 nM (Kd)

Molecular Weight

292.25

Formula

C₁₂H₁₂N₄O₅

CAS No.

22242-96-2

SMILES

O=C1C2=C(N([[email protected]@H]3O[[email protected]](CO)[[email protected]@H](O)[[email protected]]3O)C=C2C#N)N=CN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (142.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4217 mL 17.1086 mL 34.2173 mL
5 mM 0.6843 mL 3.4217 mL 6.8435 mL
10 mM 0.3422 mL 1.7109 mL 3.4217 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Jaspamycin7-CN-7-C-InoPKAParasiteProtein kinase AInhibitorinhibitorinhibit

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Jaspamycin
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