1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA
  3. Jaspamycin

Jaspamycin (Synonyms: 7-CN-7-C-Ino)

Cat. No.: HY-111759
Handling Instructions

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.

For research use only. We do not sell to patients.

Jaspamycin Chemical Structure

Jaspamycin Chemical Structure

CAS No. : 22242-96-2

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Description

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].

IC50 & Target[1]

Trypanosoma brucei PKAR(199-499)

6.5 nM (EC50)

Trypanosoma brucei PKA holoenzyme

8 nM (Kd)

Molecular Weight

292.25

Formula

C₁₂H₁₂N₄O₅

CAS No.

22242-96-2

SMILES

O=C1C2=C(N([[email protected]@H]3O[[email protected]](CO)[[email protected]@H](O)[[email protected]]3O)C=C2C#N)N=CN1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Jaspamycin
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