1. Metabolic Enzyme/Protease
    Anti-infection
  2. Cytochrome P450
    Fungal
    Parasite
  3. SDZ285428

SDZ285428 

Cat. No.: HY-108938
Handling Instructions

SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h).

For research use only. We do not sell to patients.

SDZ285428 Chemical Structure

SDZ285428 Chemical Structure

CAS No. : 174262-13-6

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Description

SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h)[1].

IC50 & Target[1]

CYP51

 

In Vivo

Specific inhibition of protozoan CYP51 can potentially provide treatment for human trypanosomiases[1].

Molecular Weight

401.89

Formula

C₂₄H₂₀ClN₃O

CAS No.

174262-13-6

SMILES

O=C(C1=CC=C(C2=CC=C(Cl)C=C2)C=C1)NCC(N3C=CN=C3)C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SDZ285428SDZ 285428SDZ-285428Cytochrome P450FungalParasiteCYPsCYP51AntifungalAntitrypanosomalparasitesInhibitorinhibitorinhibit

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SDZ285428
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