1. MAPK/ERK Pathway
    PI3K/Akt/mTOR
    Autophagy
    Apoptosis
  2. JNK
    mTOR
    Akt
    PDK-1
    Autophagy
    Apoptosis
  3. Polyphyllin I

Polyphyllin I 

Cat. No.: HY-N0047 Purity: >98.0%
Handling Instructions

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis.

For research use only. We do not sell to patients.

Polyphyllin I Chemical Structure

Polyphyllin I Chemical Structure

CAS No. : 50773-41-6

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5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].

IC50 & Target

JNK signaling[2]
PDK1/Akt/mTOR signaling[3]

Molecular Weight

855.02

Formula

C₄₄H₇₀O₁₆

CAS No.

50773-41-6

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (116.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1696 mL 5.8478 mL 11.6956 mL
5 mM 0.2339 mL 1.1696 mL 2.3391 mL
10 mM 0.1170 mL 0.5848 mL 1.1696 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Polyphyllin IJNKmTORAktPDK-1AutophagyApoptosisc-Jun N-terminal kinaseMammalian target of RapamycinPKBProtein kinase BPhosphoinositide dependent protein kinase-1Inhibitorinhibitorinhibit

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Product Name:
Polyphyllin I
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HY-N0047
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