1. MAPK/ERK Pathway
    PI3K/Akt/mTOR
    Autophagy
    Apoptosis
  2. JNK
    mTOR
    Akt
    PDK-1
    Autophagy
    Apoptosis
  3. Polyphyllin I

Polyphyllin I 

Cat. No.: HY-N0047 Purity: 99.61%
Handling Instructions

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis.

For research use only. We do not sell to patients.

Polyphyllin I Chemical Structure

Polyphyllin I Chemical Structure

CAS No. : 50773-41-6

Size Price Stock Quantity
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
20 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Polyphyllin I

    Polyphyllin I purchased from MCE. Usage Cited in: FASEB J. 2020 Oct 18.

    HEK293-T cells are co-transfected with pFUW vector and tau plasmids, or pFUW-CIP2A and tau plasmids, with or without Polyphyllin I (PPI; 0.5 or 1.0 μM) incubation for 48 h.

    View All JNK Isoform Specific Products:

    View All mTOR Isoform Specific Products:

    View All Akt Isoform Specific Products:

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].

    IC50 & Target

    JNK signaling[2]
    PDK1/Akt/mTOR signaling[3]

    Molecular Weight

    855.02

    Formula

    C₄₄H₇₀O₁₆

    CAS No.

    50773-41-6

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (116.96 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1696 mL 5.8478 mL 11.6956 mL
    5 mM 0.2339 mL 1.1696 mL 2.3391 mL
    10 mM 0.1170 mL 0.5848 mL 1.1696 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.61%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Polyphyllin IJNKmTORAktPDK-1AutophagyApoptosisc-Jun N-terminal kinaseMammalian target of RapamycinPKBProtein kinase BPhosphoinositide dependent protein kinase-1Inhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Polyphyllin I
    Cat. No.:
    HY-N0047
    Quantity:
    MCE Japan Authorized Agent: