1. MAPK/ERK Pathway
    PI3K/Akt/mTOR
    Autophagy
    Apoptosis
  2. JNK
    mTOR
    Akt
    PDK-1
    Autophagy
    Apoptosis
  3. Polyphyllin I

Polyphyllin I 

Cat. No.: HY-N0047
Handling Instructions

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis.

For research use only. We do not sell to patients.

Polyphyllin I Chemical Structure

Polyphyllin I Chemical Structure

CAS No. : 50773-41-6

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Description

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].

IC50 & Target

JNK signaling[2]
PDK1/Akt/mTOR signaling[3]

Molecular Weight

855.02

Formula

C₄₄H₇₀O₁₆

CAS No.

50773-41-6

SMILES
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Polyphyllin I
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HY-N0047
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