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Cat. No.: HY-W726633

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Boxidine

Boxidine is an orally active DHCR7 inhibitor. Boxidine inhibits DHCR7, blocks the conversion of 7-Dehydrocholesterol (HY-113279) to Cholesterol (HY-N0322), reduces serum cholesterol levels, causes accumulation of 7-dehydrocholesterol in serum and tissues, and inhibits sterol absorption. Boxidine exhibits antiproliferative and anticancer activities, with marginal activity against mouse tumors. Boxidine can be used in research related to diseases such as tumors and adrenal cancer.

For research use only. We do not sell to patients.

CAS No.: 10355-14-3
Formula: C₁₉H₂₀F₃NO
Molecular Weight:335.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Boxidine Chemical Structure

CAS No.: 10355-14-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target^[1]^[2]

DHCR7

All Endogenous Metabolite Isoforms :

In Vitro

Boxidine inhibits DHCR7 activity in cells, leading to 7-dehydrocholesterol accumulation, and displays antiproliferative and anticancer properties^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 10355-14-3
Molecular Weight 335.37
Formula C₁₉H₂₀F₃NO
SMILES

FC(F)(F)C1=CC=C(C=C1)C=2C=CC(OCCN3CCCC3)=CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gailani S, et al. Effects of boxidine on human serum sterols and neoplasms. Clin Pharmacol Ther. 1972;13(1):91-96. [Content Brief]

[2]. Dalenc F, et al. Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties. Current medicinal chemistry. 2015;22(30):3533-49. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Boxidine

All Endogenous Metabolite Isoforms