10355-14-3
Chemical Structure
Boxidine
- CAS No.: 10355-14-3
- Formula:C19H20F3NO
- Molecular Weight:335.37
IUPAC Name: 1-(2-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)oxy)ethyl)pyrrolidine
InChIKey: FOCUKKUAGZPPCU-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC=C(C=C1)C=2C=CC(OCCN3CCCC3)=CC2
Biological Activity: Boxidine is an orally active DHCR7 inhibitor. Boxidine inhibits DHCR7, blocks the conversion of 7-Dehydrocholesterol (HY-113279) to Cholesterol (HY-N0322), reduces serum cholesterol levels, causes accumulation of 7-dehydrocholesterol in serum and tissues, and inhibits sterol absorption. Boxidine exhibits antiproliferative and anticancer activities, with marginal activity against mouse tumors. Boxidine can be used in research related to diseases such as tumors and adrenal cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Boxidine | Boxidine is an orally active DHCR7 inhibitor. Boxidine inhibits DHCR7, blocks the conversion of 7-Dehydrocholesterol (HY-113279) to Cholesterol (HY-N0322), reduces serum cholesterol levels, causes accumulation of 7-dehydrocholesterol in serum and tissues, and inhibits sterol absorption. Boxidine exhibits antiproliferative and anticancer activities, with marginal activity against mouse tumors. Boxidine can be used in research related to diseases such as tumors and adrenal cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Gailani S, et al. Effects of boxidine on human serum sterols and neoplasms. Clin Pharmacol Ther. 1972;13(1):91-96. [Content Brief]
- [2]. Dalenc F, et al. Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties. Current medicinal chemistry. 2015;22(30):3533-49. [Content Brief]
Keywords
