7659-29-2
7659-29-2
Chemical Structure
3,5-Dinitrocatechol
Synonym(s): OR-486; 3,5-Dinitropyrocatechol
- CAS. Nr.: 7659-29-2
- Formula:C6H4N2O6
- Molecular Weight:200.11
IUPAC Name: 3,5-dinitrobenzene-1,2-diol
InChIKey: VDCDWNDTNSWDFJ-UHFFFAOYSA-N
SMILES: OC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O
Biological Activity: 3,5-Dinitrocatechol (OR-486) is an orally active, blood-brain barrier-permeable selective catechol-O-methyltransferase (COMT) inhibitor. 3,5-Dinitrocatechol can be used in research related to Parkinson's disease, pheochromocytoma and adult cataract[1][2][3][4][5].
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3,5-Dinitrocatechol | 99.72% | 3,5-Dinitrocatechol (OR-486) is an orally active, blood-brain barrier-permeable selective catechol-O-methyltransferase (COMT) inhibitor. 3,5-Dinitrocatechol can be used in research related to Parkinson's disease, pheochromocytoma and adult cataract. | ||||||||||||||||||||
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3,5-Dinitrocatechol (Standard) | ≥98% | 3,5-Dinitrocatechol (Standard) (OR-486 (Standard); 3,5-Dinitropyrocatechol (Standard)) is the analytical standard of 3,5-Dinitrocatechol (HY-100959). This product is intended for research and analytical applications. 3,5-Dinitrocatechol (OR-486) is an orally active, blood-brain barrier-permeable selective catechol-O-methyltransferase (COMT) inhibitor. 3,5-Dinitrocatechol can be used in research related to Parkinson's disease, pheochromocytoma and adult cataract. | ||||||||||||||||||||
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References
- [1]. Nissinen E, et al. Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. European journal of pharmacology. 1988 Aug 24;153(2-3):263-9. [Content Brief]
- [2]. Yamaki F, et al. Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta. Biological & pharmaceutical bulletin. 2020;43(3):493-502. [Content Brief]
- [3]. Cornish KM, et al. Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. Free radical biology & medicine. 2002 Jul 01;33(1):63-70.
- [4]. Steffen Y, et al. (-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase. Biochemical and biophysical research communications. 2007 Aug 03;359(3):828-33.
- [5]. Vieira-Coelho MA, et al. Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase. Brain research. 1999 Mar 06;821(1):69-78. [Content Brief]
