7659-29-2
7659-29-2
Chemical Structure
3,5-Dinitrocatechol
Synonym(s): OR-486; 3,5-Dinitropyrocatechol
- CAS No.: 7659-29-2
- Formula:C6H4N2O6
- Molecular Weight:200.11
IUPAC Name: 3,5-dinitrobenzene-1,2-diol
InChIKey: VDCDWNDTNSWDFJ-UHFFFAOYSA-N
SMILES: OC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O
Biological Activity: 3,5-Dinitrocatechol (OR-486) is an orally active, blood-brain barrier-permeable selective catechol-O-methyltransferase (COMT) inhibitor. 3,5-Dinitrocatechol can be used in research related to Parkinson's disease, pheochromocytoma and adult cataract[1][2][3][4][5].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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3,5-Dinitrocatechol | 99.72% | 3,5-Dinitrocatechol (OR-486) is an orally active, blood-brain barrier-permeable selective catechol-O-methyltransferase (COMT) inhibitor. 3,5-Dinitrocatechol can be used in research related to Parkinson's disease, pheochromocytoma and adult cataract. | ||||||||||||||||||||
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3,5-Dinitrocatechol (Standard) | ≥98% | 3,5-Dinitrocatechol (Standard) (OR-486 (Standard); 3,5-Dinitropyrocatechol (Standard)) is the analytical standard of 3,5-Dinitrocatechol (HY-100959). This product is intended for research and analytical applications. 3,5-Dinitrocatechol (OR-486) is an orally active, blood-brain barrier-permeable selective catechol-O-methyltransferase (COMT) inhibitor. 3,5-Dinitrocatechol can be used in research related to Parkinson's disease, pheochromocytoma and adult cataract. | ||||||||||||||||||||
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4-Hydroxy-5-methoxy-2-nitrobenzoic acid | 99.10% | 4-Hydroxy-5-methoxy-2-nitrobenzoic acid is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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3-Hydroxy-4-nitrobenzoic acid | 99.71% | 3-Hydroxy-4-nitrobenzoic acid is a substituted nitrobenzoic acid and synthetic intermediate. 3-Hydroxy-4-nitrobenzoic acid can serve as a starting material for acyloxy nitrobenzoic acid phospholipase A2 substrates, and also as a precursor and hydrolysis product of phospholipase A2 substrate esters, can provide a spectrophotometric signal in the form of nitrophenolate for monitoring phospholipase A2-catalyzed hydrolysis, and can be used in the preparation of BAPTA derivative chelators. | ||||||||||||||||||||
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4-Hydroxy-3-methoxy-5-nitrobenzoic acid | 99.94% | 4-Hydroxy-3-methoxy-5-nitrobenzoic acid (3-Nitro-4-hydroxy-5-methoxybenzoic acid) is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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Nitromide (Standard) | ≥98% | Nitromide (Standard) is the analytical standard of Nitromide. This product is intended for research and analytical applications. 0 | ||||||||||||||||||||
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1,5-Dichloro-2,4-dinitrobenzene-13C6 | 99% | 1,5-Dichloro-2,4-dinitrobenzene-13C6 is the 13C labeled 1,5-Dichloro-2,4-dinitrobenzene. | ||||||||||||||||||||
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3,5-Dinitrobenzoic acid (Standard) | ≥98% | 3,5-Dinitrobenzoic acid (Standard) is the analytical standard of 3,5-Dinitrobenzoic acid. This product is intended for research and analytical applications. | ||||||||||||||||||||
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2-Hydroxy-5-nitrobenzoic acid, 99% | 99.88% | 2-Hydroxy-5-nitrobenzoic acid, 99% (Anilotic acid, 99%) is a basic chemical raw material and organic synthesis intermediate that can be used to synthesize Mesalamine (HY-15027). 2-Hydroxy-5-nitrobenzoic acid, 99% is a matrix for ultraviolet matrix-assisted laser desorption/ionization (UV-MALDI) mass spectrometry. 2-Hydroxy-5-nitrobenzoic acid, 99% can also serve as an HPLC analytical standard, pH indicator, and heavy metal detection agent. 2-Hydroxy-5-nitrobenzoic acid, 99% can also be used to study the oxidation of phenolic compounds. | ||||||||||||||||||||
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Nitroxynil | 98.92% | Nitroxynil is a broad-spectrum veterinary anthelmintic and a substrate of ABCG2. Nitroxynil inhibits ATP production by uncoupling the oxidative phosphorylation process of mitochondria, thereby disrupting the parasite body covering, impairing its motility, and ultimately inducing parasite death. Nitroxynil induces chromosomal aberrations, sister chromatid exchanges and abnormal sperm morphology, and interferes with spermatogenesis. Nitroxynil is widely applicable to studies on fascioliasis, myiasis, Haemonchus spp. infections, and Oestrus ovis infections. | ||||||||||||||||||||
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4-Nitrocatechol (Standard) | ≥98% | 4-Nitrocatechol (Standard) is the analytical standard of 4-Nitrocatechol (HY-W066890). This product is intended for research and analytical applications. 4-Nitrocatechol is a Lipoxygenase inhibitor. 4-Nitrocatechol can serve as a ligand to stabilize the formation of metal complexes. As a (+) MALDI matrix, 4-Nitrocatechol significantly enhances the MALDI-MS detection and imaging of low-molecular-weight compounds in animal and plant tissue sections. | ||||||||||||||||||||
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Formaldehyde 2,4-Dinitrophenylhydrazone-13C | Formaldehyde 2,4-Dinitrophenylhydrazone-13C is the 13C-labeled 1-(2,4-Dinitrophenyl)-2-methylenehydrazine (HY-W290520). | |||||||||||||||||||||
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References
- [1]. Nissinen E, et al. Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. European journal of pharmacology. 1988 Aug 24;153(2-3):263-9. [Content Brief]
- [2]. Yamaki F, et al. Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta. Biological & pharmaceutical bulletin. 2020;43(3):493-502. [Content Brief]
- [3]. Cornish KM, et al. Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. Free radical biology & medicine. 2002 Jul 01;33(1):63-70.
- [4]. Steffen Y, et al. (-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase. Biochemical and biophysical research communications. 2007 Aug 03;359(3):828-33.
- [5]. Vieira-Coelho MA, et al. Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase. Brain research. 1999 Mar 06;821(1):69-78. [Content Brief]
