23734-88-5
Chemical Structure
Aminoglutethimide phosphate
Synonym(s): DL-Aminoglutethimide phosphate
- CAS. Nr.: 23734-88-5
- Formula:C13H19N2O6P
- Molecular Weight:330.27
IUPAC Name: 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione phosphate
InChIKey: TXHYGJUNRXVGNI-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC)(CC1)C2=CC=C(C=C2)N)=O.O=P(O)(O)O
Biological Activity: Aminoglutethimide phosphate (DL-Aminoglutethimide phosphate) is an orally active anticonvulsant with various endocrine-related side effects. Aminoglutethimide phosphate blocks multiple steroid hormone synthesis pathways by inhibiting several cytochrome P-450-dependent hydroxylases, such as aromatase, cholesterol side-chain cleavage enzyme, 11-hydroxylase, and 18-hydroxylase, with IC50 values of 0.3, 3.5, 120, and 20 μM, respectively. Aminoglutethimide phosphate reduces cortisol levels. Aminoglutethimide phosphate can be used in research on Cushing's syndrome, breast cancer, and other conditions[1][2][3][4].
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Aminoglutethimide phosphate | Aminoglutethimide phosphate (DL-Aminoglutethimide phosphate) is an orally active anticonvulsant with various endocrine-related side effects. Aminoglutethimide phosphate blocks multiple steroid hormone synthesis pathways by inhibiting several cytochrome P-450-dependent hydroxylases, such as aromatase, cholesterol side-chain cleavage enzyme, 11-hydroxylase, and 18-hydroxylase, with IC50 values of 0.3, 3.5, 120, and 20 μM, respectively. Aminoglutethimide phosphate reduces cortisol levels. Aminoglutethimide phosphate can be used in research on Cushing's syndrome, breast cancer, and other conditions. | |||||||||||||||||||||
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- [1]. Santen RJ, et al. Aminoglutethimide: review of pharmacology and clinical use. Pharmacotherapy. 1981;1(2):95-120. [Content Brief]
- [2]. Cocconi G, et al. First generation aromatase inhibitors--aminoglutethimide and testololactone. Breast Cancer Res Treat. 1994;30(1):57-80. [Content Brief]
- [3]. Mutsuga M, et al. Aminoglutethimide-induced lysosomal changes in adrenal gland in mice. Exp Toxicol Pathol. 2017;69(7):424-429. [Content Brief]
- [4]. Hughss SW, et al. Aminoglutethimide: a "side-effect" turned to therapeutic advantage. Postgrad Med J. 1970;46(537):409-416. [Content Brief]
Keywords
